Cervical ripening prior to induction of labor (intracervical application of a PG E2 viscous gel)

Steiner, H; Zahradnik, H. P.; Breckwoldt, M.; Robrecht, D; Hillemanns, H. G.

doi:10.1016/0090-6980(79)90084-4

Cited by 18 publications

(6 citation statements)

References 12 publications

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“…The contribution that labour makes to scar rupture is not obvious as Case et a1 (1971) found that the incidence of ruptured or 'windowed' scars (approximately 8%) was similar following labour and elective section. Vigilance is important following prostaglandin treatment since uterine rupture has been reported even in the absence of previous surgery (Bromham & Anderson 1980;Geirsson 1981; Scott & Lichter 198 1) but we believe the risks are small due to the low amplitude, frequent uterine contractions provoked by the prostaglandins (MacKenzie & Embrey 1977;Steiner et al 1979). But the use of additional oxytocics to augment a slowing labour following a prostaglandin induction must be used with extreme caution.…”

Section: Discussionmentioning

confidence: 99%

Vaginal prostaglandins and labour induction for patients previously delivered by caesarean section

Mackenzie

Bradley

Embrey

1984

BJOG

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Summary. Labour was induced at term with vaginal instillation of prostaglandin E2 in 143 patients who had been delivered by caesarean section in a previous pregnancy. The method was simple, safe and effective with 76% achieving a vaginal delivery, and even when the cervix was very unfavourable at the time of prostaglandin treatment, 68% achieved vaginal delivery. The procedure reduces the need for repeat caesarean section with its potential morbidity, without evidence of undue risk of lower segment scar rupture.

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Section: Discussionmentioning

confidence: 99%

Vaginal prostaglandins and labour induction for patients previously delivered by caesarean section

Mackenzie

Bradley

Embrey

1984

BJOG

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“…incubated with PGE2 or P G F h exhibited an augmented net incorporation of radioactivity, whereas in the early (days [16][17][18][19][20][21][22] as well as in the late (days 23 -28) luteal phase a reduction of radiolabelling was seen (Fig. 4).…”

Section: -14)mentioning

confidence: 99%

Acute Effects of Prostaglandins on the Biosynthesis of Connective Tissue Constituents in the Non‐Pregnant Human Cervix Uteri

Norström

1984

Acta Obstet Gynecol Scand

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Biochemical effects of prostaglandins (PGs) on the connective tissue of the human cervix uteri were studied by measuring the net incorporation of [3H] glycine and [3H] glucosamine into cervical specimens, incubated in vitro in the presence of PGE2 and PGF2 alpha. The net radiolabelling with these isotopes, precursors of collagen and proteoglycans, was influenced by PGE2 and PGF2 alpha in a similar manner. In the follicular phase of the menstrual cycle, both PGs induced a decreased radiolabelling with glycine but caused an increased labelling with glucosamine. In the luteal phase, the situation was reversed, i.e. the incorporation of glycine was augmented and that of glucosamine was reduced in tissue incubated with PGs. It is suggested that PGs can modulate the fibroblast biosynthesis activity in such a way that either the synthesis of fibrous structures (collagen) or that of ground substance constituents (proteoglycans) is favored.

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“…Unfavorable cervix is associated with longer duration of labor and higher rate of failure, requiring an emergency caesarean delivery. Performing pre-induction cervical ripening improves the success rate of labor induction (2). There are various methods available and ideally, it should be effective, safe with minimal side effects to mother and fetus, cheap, easy storage, stable at room temperature and associated with high patient's satisfaction.…”

Section: Introductionmentioning

confidence: 99%

Prospective randomized controlled trial comparing inpatient and outpatient Foley catheter cervical ripening

Rahman

Mohamad

Kalok

et al. 2020

Preprint

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Background To evaluate the safety of Foley catheter cervical ripening and patients’ satisfaction in outpatient versus inpatient setting. Methods Sixty low risk women were randomized to outpatient (n = 25) and inpatient (n = 35) cervical ripening using Foley catheter. In both groups Foley catheter with 60 ml balloon was digitally inserted through the cervix with gentle traction applied. The outpatient group was discharged home after provision of verbal and written 24-hours contact information and instructions. The inpatient group was admitted to the ward. They were reassessed the next morning unless labor had begun or the catheter had dropped off. Results The demographic data between the two groups did not differ. The outpatient group has significant improvement in the Bishop score at second assessment (9.04 versus 7.89, p = 0.04), reduced duration of inpatient stay (41 versus 59, p < 0.001), able to sleep 5–6 hours (9 versus 1, p = 0.001), able to rest (23 versus 16, p = 0.001) and relax (23 versus 10, p < 0.001). Significantly, more women in the inpatient group had wished to be in the outpatient group (3 versus 21, p < 0.001). There was no difference in initial Bishop score, duration of oxytocin infusion and delivery within 24 hours. Both groups were similar in caesarean section rate, total blood loss, maternal and neonatal infection, primary postpartum hemorrhage, neonatal birthweight and cord pH. There was no incidence of uterine hyperstimulation, meconium aspiration syndrome and neonatal intensive care unit admission. Conclusion Outpatient Foley catheter cervical ripening had comparable efficacy and safety with inpatient for low-risk pregnancies and associated with better patient satisfaction. Trial registration: NCT04342741. It was retrospectively registered with ClinicalTrial.gov

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Cervical ripening prior to induction of labor (intracervical application of a PG E2 viscous gel)

Cited by 18 publications

References 12 publications

Vaginal prostaglandins and labour induction for patients previously delivered by caesarean section

Vaginal prostaglandins and labour induction for patients previously delivered by caesarean section

Acute Effects of Prostaglandins on the Biosynthesis of Connective Tissue Constituents in the Non‐Pregnant Human Cervix Uteri

Prospective randomized controlled trial comparing inpatient and outpatient Foley catheter cervical ripening

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