Early squamous cell carcinoma of the uterine cervix II. Clinical results of a cooperative study in the management of 419 patients with early stromal invasion and microcarcinoma

Lohe, K. J.; Burghardt, E; Hillemanns, H. G.; Kaufmann, C.; Ober, K. G.; Zander, J.

doi:10.1016/0090-8258(78)90004-5

Cited by 69 publications

(13 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fewer studies report mortality figures and recurrence rates for microinvasive cervical cancer with stromal invasion r1.0 mm without LVSI alone. Prior reviews comprising 1875 women report mortality figures of 0% to 0.1% (7,12). We found only 4 women to have recurrent CIN only, no women had recurrent stromal invasion or worse, and our mortality rate was 0 (0/716 women years of follow-up) although we acknowledge that some of our women have short-term follow-up only.…”

Section: Discussioncontrasting

confidence: 47%

“…Conservative surgical management utilizing localized excision techniques, or where appropriate simple hysterectomy, have therefore been used for many years (8,10,12,15). The cancer mortality from Stage 1A disease is reported as being o1% to 1.9% (8,(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…ESI is defined as isolated variably shaped tumor projections into the subepithelial connective tissue (10)(11)(12). In ESI, the invasive tongues extend into the stroma either from the surface epithelium or from the base of CIN-affected crypts (13), and measure no more than 1 mm in maximum depth (8,14).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Outcome for Women With Microinvasive Cervical Cancer With Stromal Invasion 1 mm or Less

Palmer

Amarad

Ellis

et al. 2012

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

To assess the management and outcome for women with microinvasive cervical cancer with stromal invasion 1 mm or less, examining the impact of re-excision. A retrospective cohort study with interval analysis performed between December 2000 and December 2010. Sheffield Gynaecological Cancer Centre and Jessop Wing Colposcopy Unit, Sheffield, UK. Women diagnosed with microinvasive cervical cancer with stromal invasion 1 mm or less during the allocated study period. Methods used is a retrospective cohort study. Risk of recurrence and mortality from disease; incidence of residual disease in repeat excision specimens. A total of 140 women were identified as having microinvasive cervical cancer with stromal invasion 1 mm or less. Sixty-three (45%) had a completely excised lesion; 77 (55%) had an incompletely excised lesion at first treatment. Fifty-five women underwent repeat excision. No residual disease was found in the majority (n=40; 73%). No women suffered disease recurrence or died from disease during the allocated study period. Outcome for women with microinvasive cervical cancer with stromal invasion 1 mm or less is excellent. Repeat excision is associated with very low rates of residual disease. A more conservative approach to follow-up incorporating HPV testing should be explored.

show abstract

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Outcome for Women With Microinvasive Cervical Cancer With Stromal Invasion 1 mm or Less

Palmer

Amarad

Ellis

et al. 2012

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5][6][7][8][9][10] Although much of the prior literature has included both stage IA1 and IA2 patients, those with stromal invasion of less than 3 mm seem to have a risk of recurrence of less than 2% and a risk of death of only 0.1%. 3,4,6,7 Burghardt et al 4 analyzed a cohort of 344 patients with stage IA1 cervical cancer and noted only one (0.3%) recurrence that was diagnosed 12 years after treatment with conization. A recent review of the literature suggested that lymphvascular space invasion is an important risk factor for nodal metastases and death for women with IA1 tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Given the excellent prognosis of patients with stage IA1 cervical cancer, fertility-conserving therapy with conization has been proposed as an alternative to hysterectomy for young women. [2][3][4][5][6][7][8][9][10] Although small institutional series and case control studies have suggested that conization is safe, large studies comparing conization and hysterectomy for stage IA1 cervical cancer are largely lacking. The objective of our study was to examine the safety of fertility-conserving conization in a large cohort of young women with stage IA1 squamous cell carcinoma of the cervix.…”

mentioning

confidence: 99%