Streptozotocin-diabetic rats were treated with di-isopropylammonium dichloroacetate (DIPA) via an orogastric tube in doses of 25 or 50 mg./l kg. twice daily for one week. In nonketotic animals, mean blood glucose concentration decreased significantly during treatment with either DIPA or its acid moiety, sodium dichloroacetate. Neither di-isopropylammonium hydrochloride nor saline reduced hyperglycemia in the diabetic rats. There was no change in the blood glucose of nondiabetic rats in response to DIPA. In ketotic diabetes produced by streptozotocin, 63 per cent of DIPA-treated animals survived after one week, compared to 24 per cent of those given saline. DIPA did not influence glucose absorption in isolated everted jejunal sacs from diabetic and normal rats, while phenformin inhibited transport by more than 50 p_er cent Thus DIPA, which only partially mimics insulin in its actions and does not stimulate insulin release as do the sulfonylureas, also fails to duplicate the effects of phenformin and appears to have a unique mode of action. DIPA is an effective oral hypoglycemic agent in streptozotocin-diabetic rats. DIABETES 25: 179-82, March, 1974.
In cooperation with the firm of Richard Wolf, a new ear telescope has been developed which facilitates the diagnosis and documentation of tympanic membrane lesions. This 6.8 mm telescope of the Lumina type is prevented from misting up by a stream of air directed across the distal viewing window. This 6.8 mm Lumina telescope also formed the basis for a completely newly developed optical system for middle ear endoscopy. This combined optical system comprising a mother and baby scope has been undergoing trials for the past 18 months. The baby scope can be passed through the mother scope, thus permitting inspection of the tympanic cavity, under direct vision and unaffected by involuntary movements of the patients. The particular configuration of this system makes it easy for the endoscopist to apply his eye first to one and then to the other telescope. The 6.8 mm mother scope and the 2.7 mm baby scope can both be connected to a camera which provides high-quality pictures the dimension of which are only a little smaller than those of a slide.
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