Objectives: 1-Describe the anatomical bases related to the concept of the functional endoscopic tympanic surgery (FETS) based on the fact that restoring adequate tympanic cavity ventilation is one of the main key factors to achieve this concept and restore normal middle ear functions. 2-Review and explain the possible theory and concept of the FETS in relation to these bases. Methods: Fifty-five temporal bones were dissected, and the ventilation pathways were studied utilizing otoendoscopes of different angles and an operating microscope. In addition, the anatomy and relations of these pathways were studied in 200 temporal bones computed tomography scans (CT). Results: The ventilation pathways of the tympanic cavity (with all of its subdivisions) and the mastoid air cells were variable and unique for each temporal bone. Basically, the ventilation patterns could be classified either directly from the eustachian tube or indirectly through communicating with other spaces via mucosal, ligamental and/or bony apertures or isthmi. Mesotympanum, protympanum, hypotympanum and anterior epitympanum type C were the only spaces directly ventilated, while retrotympanum with all of its recesses, anterior epitympanum types A and B, Prussak's space, von Troeltsch pouches, compartments of posterior epitympanum (medial and lateral superior and medial incudal spaces), antrum and mastoid air cells were indirectly ventilated. It was possible to approach most of the pathways endoscopically via transcanal or combined transcanal and transmastoid approaches. Conclusions: Theoretically, ventilation pathways could be endoscopically approached and therefore restored in certain cases. CT scans are a possible tool to study them.