Summary
Seventeen cases of guttural pouch mycosis (including two bilaterally affected cases) were diagnosed in a three year period. The presenting signs were, in order of frequency, epistaxis at rest, nasal catarrh, pharyngeal paralysis, ipsilateral laryngeal hemiplegia, swelling of the submandibular/parotid region, extension of the head and neck and dyspnoea. Ligation of the origin of the internal carotid and occipital arteries was attempted in 10 of the cases exhibiting epistaxis. Bilateral ligation was performed on one animal with an untoward sequelae. Where surgery was successfully completed further haemorrhage was prevented in eight out of nine affected pouches (89 per cent). Medical treatment involving local administration of various antifungal preparations via a specially designed catheter and/or the oral administration of benzimidazole drugs was successful in eliminating the mycotic plaque in most cases. Cases which presented with pharyngeal paralysis were all fatal.
SUMMARY
This paper records the clinical and postmortem findings in a mare with diabetes mellitus. The main features were rapid emaciation, abnormal glucose tolerance and no response to insulin. At postmortem examination a tumour of the pars intermedia of the pituitary, adrenal cortical hyperplasia and depletion of the β cells of the pancreatic islets were the principal findings. The literature on this syndrome in the horse has been reviewed.
RÉSUMÉ
Cet article donne un compte rendu clinique et nécrop‐sique d'un cas de diabète sucré chez une jument. Les signes principaux étaient un amaigrissement rapide, une tolérance anormale au glucose et l'absence de réponse à l'insuline.
A l'autopsie on a trouvé une tumeur de la pars intermedia de l'hypophyse, une hyperplasie du cortex surrenal et une déplétion des cellules beta des ilots pancréatiques. Une revue de la littérature est donnée.
ZUSAMMENFASSUNG
Dieser Artikel beschreibt die klinischen und pathologischen Befunde bei einer Stute mit Diabetes mellitus. Die hervorstechenden Symptome bestanden in rascher Abmagerung und Entkräftung, in einer abnormen Glukosetoleranz und einer fehlenden Reaktion auf Insulin. Bei der Autopsie fand sich ein Tumor der pars intermedia der Hypophyse, eine Hyperplasie der Neben‐nierenrinde und eine Verminderung von β‐Zellen in den Pankreasinseln. Die Literatur über dieses Syndrom beim Pferd wird besprochen.
The fragilitas ossium (fro/fro) mutation in the mouse has been demonstrated to have clinical, radiographic and morphologic manifestations similar to those which arise in autosomal recessive forms of osteogenesis imperfecta (OI) occurring in humans. Approximately 90% of mutant offspring in the mouse were perinatally lethal with clinical and roentgenographic findings similar to those of OI type II subgroup A in humans. The 10% of mutant mice surviving follow a course very similar to severe progressively deforming OI type III. In surviving mice, there is progressive fore-limb and hind-limb bowing in the absence of a high fracture frequency.
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