Renal carcinomatosis in a horse

West, H.J.; Kelly, D. F.; Ritchie, H.E.

doi:10.1111/j.2042-3306.1987.tb02671.x

Cited by 32 publications

(36 citation statements)

References 5 publications

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“…Platelet counts were normal except in 2 of the 15 (13%) horses in which thrombocytopenia was present. 6,21 Serum biochemical analysis was reported for 23 horses. Of these, 4 horses were hypoglycemic (17%) and 3 were mildly azotemic (13%), with increases in serum creatinine (0.9 nmol/L; reference range, 0.08-0.16) and blood urea nitrogen (10.5 nmol/L; reference range, 3.5-8.0).…”

Section: Resultsmentioning

confidence: 99%

“…18,19 One sample was grossly serosanguineous but with normal cell count and protein concentration. 21 One horse had a large amount of peritoneal fluid classified as a exudate with an increased nucleated cell count and protein concentration. 5 One horse had a modified transudate without evidence of neoplasia.…”

Section: Resultsmentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The medical records for the Veterinary Teaching Hospital at Washington State University were also searched for cases that had a histopathologically confirmed diagnosis of renal carcinoma or adenocarcinoma. Information collected included signalment, presenting complaint, history, duration of clinical signs, physical examination findings, clinicopathologic data, diagnostic results including imaging studies, survival time, outcome, gross and histopathologic necropsy findings, and final diagnosis.…”

Section: Methodsmentioning

confidence: 99%

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A Retrospective Analysis of Renal Carcinoma in the Horse

Wise

Bryan

Sellon

et al. 2009

Veterinary Internal Medicne

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Background: Renal carcinoma is a rare tumor of horses. Hypothesis: Presenting complaints and clinical signs of this disease are vague and early diagnosis increases survival time. Animals: Data were collected from the medical records of 4 horses presented to Washington State University as well as the 23 previously published case reports of horses with renal carcinoma.Methods: Retrospective study.Results: Renal carcinoma affects horses of all ages with most cases observed in geldings and Thoroughbreds. The most common presenting complaints are nonspecific and usually do not occur until late in the course of the disease. Routine laboratory results generally are unremarkable with no evidence of renal dysfunction. Urine and peritoneal fluid analyses are consistently abnormal, but the changes usually are nonspecific. Rectal palpation often allows detection of an abnormal kidney or a mass in the area of the kidney. Renal ultrasound examination is the most rewarding imaging procedure, and when combined with renal biopsy, antemortem diagnosis can be achieved. Renal carcinoma is both locally invasive and metastatic, necessitating careful staging for metastasis using thoracic radiography and abdominal ultrasound examination. If the tumor is localized to 1 kidney, nephrectomy is the treatment of choice. No chemotherapy or radiation treatment for renal carcinoma has been reported in the horse. Median survival for this series of cases was 11 days (0 days-1 year).Conclusions and Clinical Importance: Prognosis is poor to grave.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Retrospective Analysis of Renal Carcinoma in the Horse

Wise

Bryan

Sellon

et al. 2009

Veterinary Internal Medicne

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“…Renal cell tumors are considered malignant in horses and cats; however, unlike in dogs, relatively few cases have been studied [65]. Metastases are common in horses and are widely disseminated often to the lungs and liver [70,71]. There is a report of clear cell renal carcinoma in a horse manifesting initially as an aggressive metastatic oral tumor [13].…”

Section: Malignancy and Metastasismentioning

confidence: 99%

Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review

Woldemeskel¹

2013

J Clin Exp Pathol

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Renal Cell Carcinoma (RCC) is the most common primary renal neoplasm in humans and domestic animals such as dogs, cats and horses. Various subtypes are recognized in both humans and animals. Advances in biomedical sciences have developed hitherto unprecedented extraordinary cancer therapeutic options varying from sophisticated surgery to immunotherapy and gene therapy. Treatment regimens employed, response to treatments and prognosis vary based on the subtypes of RCC, degree of malignancy, metastasis and stage of the neoplasm. Surgery is the main treatment for most RCCs. Drug resistance has long been a challenge in cancer treatment. New insights in cancer treatment such as molecular targeted therapy including nano-medicine against chemo-resistance are among the contemporary developments targeting cancers. This mini review highlights on the occurrence and significance of RCC in humans and animals, briefly summarizes the various subtypes reported and the treatment regimens executed.

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“…In horses, renal tumors account for approximately 0.011% of total tumors and renal cell carcinomas (RCC) represented half of these renal tumors (HASCHEK et al, 1981). Metastasis of equine RCC is common and has been reported in the lungs, liver, bone, contralateral kidney, heart, pancreas, intestine, adrenal glands, myocardium, and lymph nodes (BROWN & HOLT, 1985;WEST & KELLY, 1987;WISE et al, 2009). Involvement of the peritoneal cavity (carcinomatosis) in cases of RCC has been rarely reported (HASCHEK et al, 1981; VAN MOL & FRANSEN, 1986).…”

Section: Clinic and Surgerymentioning

confidence: 99%