Ondansetron 4 mg was compared with metoclopramide 10 mg for prevention of post-operative nausea and emesis in in-patients undergoing major gynaecological surgery in this double-blind, randomized, placebo-controlled, multicentre study. A total of 1044 patients received a single intravenous (i.v.) injection of study medication immediately before induction of anaesthesia. Nausea and emesis were assessed over the 24 h post-operative period. Significantly more patients who received ondansetron experienced no emetic episodes (44%) compared with those who received metoclopramide (37%, P = 0.049) or placebo (25%, P < 0.001). No nausea was experienced by significantly more patients who received ondansetron (32%) than with patients who received metoclopramide (24%, P = 0.009) or placebo (16%, P < 0.001). In addition, fewer emetic episodes, less severe nausea and a reduced need for rescue antiemetics were also observed with ondansetron (P < 0.05 vs. metoclopramide and placebo). Metoclopramide and placebo-treated patients were also 1.5 times (95% Cl 1.5-4.2) and 2.5 times (95% Cl 1.1-2.0) more likely, respectively, to experience nausea post-operatively. Overall, ondansetron was the most effective antiemetic in this patient population.
tron (32%) than with patients who received metoclopramide (24%, P=0.009) or placebo (16%, P<0.001). Ondansetron 4 mg was compared with me-In addition, fewer emetic episodes, less severe nausea toclopramide 10 mg for prevention of post-operative and a reduced need for rescue antiemetics were also nausea and emesis in in-patients undergoing major observed with ondansetron (P<0.05 vs. megynaecological surgery in this double-blind, rantoclopramide and placebo). Metoclopramide and domized, placebo-controlled, multicentre study. A placebo-treated patients were also 1.5 times (95% CI total of 1044 patients received a single intravenous 1.5-4.2) and 2.5 times (95% CI 1.1-2.0) more likely, (i.v.) injection of study medication immediately before respectively, to experience nausea post-operatively. induction of anaesthesia. Nausea and emesis were Overall, ondansetron was the most effective antiassessed over the 24 h post-operative period. Sigemetic in this patient population. nificantly more patients who received ondansetron experienced no emetic episodes (44%) compared with
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