To reveal the association of the interleukin 8 (IL-8) gene with the development and progression of oral lichen planus (OLP) we performed RT-PCR analysis of rs4073 polymorphism in the IL-8 gene in 92 oral lichen planus patients and 163 healthy individuals of Russian ethnic origin from the Volga-Ural region of Russia. The investigation showed the importance of polymorphism rs4073 of IL-8 gene for oral lichen planus development. The disease was associated with genotype rs4073*T / T which was found to be the genetic marker of high risk for oral lichen planus development, and rs4073*A / T genotype — the genetic marker of low risk for erosive-ulcerous oral lichen planus form development (p=0.016, OR=0.40) and the disease recurrence (p=0.02, OR=0.33). The results obtained in the investigation make a significant contribution to understanding the structure of hereditary predisposition to oral lichen planus development.
Aim. To search for genetic markers of oral lichen planus development and recurrence risk based on the study of polymorphic variants of tumor necrosis factor α (TNFα rs1800630, rs1800629, rs361525) and interleukin-18 (IL-18 rs187238) genes in patients from the Volga-Ural region of Russia.Methods. Standard methods of molecular genetic analysis were used in the study. Deoxyribonucleic acid was isolated from peripheral blood lymphocytes by deproteinization with phenol and chloroform. Genotyping of studied polymorphic loci was performed by real time polymerase chain reaction using TaqMan-competing probes. In order to identify the association of polymorphic loci in different models (additive, dominant, recessive, overdominant) the method of logistic regression was used.Results.. Statistical analysis using logistic regression revealed that polymorphic locus rs187238 in IL-18 gene is associated with the risk of lichen planus development in a recessive model (p=0.042). In addition, the association of a polymorphic locus rs187238 in IL-18 gene with the recurrence risk was described: rs187238*C/C genotype is a genetic marker of increased risk of oral lichen planus recurrence (p=0.01). Analysis of the association of polymorphic loci rs1800630, rs1800629, rs361525 in tumor necrosis factor α gene with the disease severity and the recurrence risk did not reveal any statistically significant results.Conclusion. The study results confirm the cytokine genes contribution to the oral lichen planus development and disease reccurrence.
For a woman’s dental health, pregnancy is a critical period, characterized by an exacerbation of inflammatory periodontal diseases before pregnancy, as well as a significant increase in dental caries. Using a significant group of drugs during pregnancy is not safe for a woman's body. In this regard, in the treatment of periodontal diseases, the inclusion of phytopreparations into the complex of treatment and prophylactic measures that can restore local immunity, reduce inflammation and accelerate the restoration of the mucous membrane, which have minimal side effects on the body as a whole, is of great importance. The aim of the work was to assess the clinical effectiveness of the local use of a new chewing phytosubstrate containing beeswax and dry aqueous boron extract, consisting of oak bark, alder fruit, birch buds, chamomile flowers and thyme grass in women with gingivitis with gestosis complicated pregnancy. Methods. A survey was conducted of 127 pregnant women, of which 79 pregnant with gestosis and 48 patients with a physiological course of pregnancy at the age of 18-34 years in the II and III trimesters. Results. The dental status and physicochemical properties of the oral fluid in women with gestational complications of pregnancy were studied before and after the application of the new phytosubstrate. Conclusions. The chewing substrate containing beeswax and dry aqueous extract consisting of oak bark, alder fruit, birch buds, chamomile flowers and thyme herbs has been found to be highly effective in the prevention and treatment of gingivitis in women with gestosis complicated pregnancy, which was confirmed by improved biochemical and physico-chemical indicators of oral fluid, as well as clinical indicators of dental status. in women with gestational complications.
Красный плоский лишай (КПЛ)-хронический, длительно протек ающий дерматоз мультифакторной природы с многообразными клиническими проявлениями и вовлечением в процесс кожи, ее придатков (волосы, ногти) и слизистых оболочек [1, 2]. Поражение слизистой оболочки полости рта (СОПР) при КПЛ может сочетаться с поражением кожи, но нередко носит изолированный характер [3, 4]. Наиболее часто процесс развивается на слизистой щек, языка, в ретромолярной области, десне, губах, реже в области дна полости рта и неба. Боле
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