Clinical features of lichen ruber planus of the oral mucosa

Chuykin, Sergey; Akmalova, Guzel'; Чернышева, Н.

doi:10.17116/klinderma201514372-75

Klin. dermatol. venerol.

2015

DOI: 10.17116/klinderma201514372-75

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Clinical features of lichen ruber planus of the oral mucosa

Sergey Chuykin¹,

Guzel' Akmalova²,

Н. Чернышева³

Abstract: Красный плоский лишай (КПЛ)-хронический, длительно протекающий дерматоз мультифакторной природы с многообразными клиническими проявлениями и вовлечением в процесс кожи, ее придатков (волосы, ногти) и слизистых оболочек [1, 2]. Поражение слизистой оболочки полости рта (СОПР) при КПЛ может сочетаться с поражением кожи, но нередко носит изолированный характер [3, 4]. Наиболее часто процесс развивается на слизистой щек, языка, в ретромолярной области, десне, губах, реже в области дна полости рта и неба. Боле

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Cited by 7 publications

References 5 publications

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Etiology, clinical manifestations, and oral microbiota in oral lichen planus: A review of the scientific literature

Teplyuk,

Stepanov,

Damdinova

et al. 2023

Russian Journal of Skin and Venereal Diseases

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Treatment of lichen planus of the oral mucosa remains one of the most complex and urgent problems in dermatovenerology and dentistry. In the article, the authors present an analysis of current scientific studies on various aspects of lichen planus of the oral mucosa, including its etiology and prevalence, clinical manifestations, as well as the potential risk of malignant transformation and the microbiota of the oral cavity in patients with this pathology. Potential factors influencing the development of the disease and the possible impact of changes in the microbiota on the clinical course of lichen planus of the oral mucosa are considered. To date, the etiopathogenetic mechanisms of the development of lichen planus of the oral mucosa remain not fully understood. The determination of pathogenesis and the use of differentiated, combined methods will allow us to propose an optimal strategy for the prevention of the disease, increase the effectiveness of its prediction and treatment. The call for further research emphasizes the need to study the red lichen planus of the oral mucosa not as an independent nosology, but as a system of complex neurohumoral and immunoallergic changes, disorders that can affect the patient's quality of life.

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Etiology, clinical manifestations, and oral microbiota in oral lichen planus: A review of the scientific literature

Teplyuk,

Stepanov,

Damdinova

et al. 2023

Russian Journal of Skin and Venereal Diseases

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The relationship of microbial biodiversity and clinical forms of oral lichen planus: analysis based on 16S rRNA sequencing

Teplyuk,

Stepanov,

Damdinova

et al. 2024

Russian Journal of Skin and Venereal Diseases

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BACKGROUND: The composition and changes of microbiota have a significant impact on overall health and the development of various diseases.Of particular relevance is the problem of changes in the oral microbiota in patients with lichen planus of the oral mucosa. Studying the relationship between the composition of the oral microbiota and the pathogenesis of oral lichen planus will improve the understanding of the mechanisms of this disease. Thus, this topic is of considerable interest to a wide range of specialists in the field of medicine and biology. AIMS: detailed analysis of oral cavity microbiota and establishment of potential pathogenetic microbial associations with oral lichen planus. MATERIALS AND METHODS: The study included samples from patients diagnosed with various forms of КПЛ СОПР(lichen planus erosive-ulcerative) and a control group. The investigation was based on analyzing microbial diversity metrics (alpha and beta diversity), relative abundance of bacterial taxa, and identification of unique bacterial taxa in the КПЛ СОПР patients. This analysis utilized the 16S rRNA sequencing method. RESULTS: The analysis revealed a rich bacterial composition in patients with OLP, which was significantly different from that in the control group. Differences were also observed between the subgroups, especially between the typical and erosive-ulcerative forms of the disease. Notably, beta diversity did not show significant differences between the groups, indicating a similar overall microbiota composition despite fluctuations in the relative abundance of species. Nevertheless, the typical clinical form of the disease demonstrated more significant differences in the microbiota structure compared to the hyperkeratotic and erosive-ulcerative forms. Furthermore, analysis of the study groups revealed the presence of 50% shared microbial species, while the other half was represented by unique species associated with OLP. Regarding the subgroups, it was found that unique microorganisms correlated with the typical and erosive-ulcerative forms, respectively, providing a deeper understanding of the specific microbiological profile in the context of this disease. CONCLUSIONS: The study confirmed the hypothesis of an association between the microbiota composition and oral lichen planus, which may be of importance for the development of novel therapeutic approaches.

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Dental Status of Women With Pregnancy Complicated With Gestosis

Chuykin

Yashchuk

Maganova

et al. 2021

Actual Problems in Dentistry

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Subject of our research is dental examination and identification of the features of the dental status in women with pregnancy complicated by gestosis. There is no doubt that pregnancy is a critical period for woman’s dental health. Objectives. Determine the dental status in women with pregnancy complicated by gestosis. Methods. As part of the study of the dental status of women with pregnancy complicated by gestosis, we conducted a clinical examination of the oral cavity in 127 women. The depth of the vestibule, the level of attachment of the bridles, the state of the bite, the indices of the KPU, IK, PMA, IZN were determined. Results. Our data indicate that the complication of the course of the third trimester of pregnancy with gestosis in women is accompanied by a deterioration in periodontal status, oral hygiene, and a 100% prevalence of gingivitis. Conclusions. The results of the study made it possible to obtain clinical and dental data characterizing the effect of pregnancy complicated by preeclampsia in women in the third trimester on the course of gingivitis, which is the basis for the development of methods for optimizing and increasing the effectiveness of therapeutic and prophylactic measures in this group of patients.

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Clinical features of lichen ruber planus of the oral mucosa

Cited by 7 publications

References 5 publications

Etiology, clinical manifestations, and oral microbiota in oral lichen planus: A review of the scientific literature

Etiology, clinical manifestations, and oral microbiota in oral lichen planus: A review of the scientific literature

The relationship of microbial biodiversity and clinical forms of oral lichen planus: analysis based on 16S rRNA sequencing

Dental Status of Women With Pregnancy Complicated With Gestosis

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