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This study suggests that indoor air-related respiratory symptoms are a matter of concern in places with hot and humid climate. The regression models were adjusted by confounders that could be used in further reanalysis of indoor air quality related symptoms and ventilation systems with expanded variety of climatic conditions.

IntroductionLeukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma.MethodsSixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks. Quantification of bronchoalveolar lavage (BAL) cellularity, leukocytes, airway remodeling, interleukin (IL)-5, IL-13, cysteinyl leukotriene (CysLT), and leukotriene B4 (LTB4) in BAL was performed. In addition, quantitative analyses on peribronchial leukocytes and airway epithelium for LT pathway agents: 5-lypoxygenase (5-LO), LTA4 hydrolase (LTA4H), CysLT1 receptor, CysLT2 receptor, LTC4 synthase, and LTB4 receptor 2 (BLT2) were performed. Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography.ResultsAE decreased eosinophils (p < 0.001), neutrophils (p > 0.001), lymphocytes (p < 0.001), and macrophages (p < 0.01) in BAL, as well as eosinophils (p < 0.01), lymphocytes (p < 0.001), and macrophages (p > 0.001) in airway walls. Collagen (p < 0.01), elastic fibers (p < 0.01), mucus production (p < 0.01), and smooth muscle thickness (p < 0.01), as well as IL-5 (p < 0.01), IL-13 (p < 0.01), CysLT (p < 0.01), and LTB4 (p < 0.01) in BAL were reduced. 5-LO (p < 0.05), LTA4H (p < 0.05), CysLT1 receptor (p < 0.001), CysLT2 receptor (p < 0.001), LTC4 synthase (p < 0.001), and BLT2 (p < 0.01) expression by peribronchial leukocytes and airway epithelium were reduced. Lastly, AHR to MCh 25 mg/mL (p < 0.05) and 50 mg/mL (p < 0.01) was reduced.ConclusionModerate-intensity AE attenuated asthma phenotype and LT production in both pulmonary leukocytes and airway epithelium of OVA-treated mice.

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Objective: To provide an update on trends in asthma mortality in Brazil for two age groups: 0-4 years and 5-34 years.Methods: Data on mortality from asthma, as defined in the International Classification of Diseases, were obtained for the 1980-2014 period from the Mortality Database maintained by the Information Technology Department of the Brazilian Unified Health Care System. To analyze time trends in standardized asthma mortality rates, we conducted an ecological time-series study, using regression models for the 0- to 4-year and 5- to 34-year age groups.Results:There was a linear trend toward a decrease in asthma mortality in both age groups, whereas there was a third-order polynomial fit in the general population.Conclusions: Although asthma mortality showed a consistent, linear decrease in individuals ≤ 34 years of age, the rate of decline was greater in the 0- to 4-year age group. The 5- to 34-year group also showed a linear decline in mortality, and the rate of that decline increased after the year 2004, when treatment with inhaled corticosteroids became more widely available. The linear decrease in asthma mortality found in both age groups contrasts with the nonlinear trend observed in the general population of Brazil. The introduction of inhaled corticosteroid use through public policies to control asthma coincided with a significant decrease in asthma mortality rates in both subsets of individuals over 5 years of age. The causes of this decline in asthma-related mortality in younger age groups continue to constitute a matter of debate.

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Resumo O objetivo deste trabalho foi comparar agravos à saúde entre grupos funcionais de trabalhadores da limpeza urbana (TLU) decorrentes de exposição biológica do contato com os Resíduos Sólidos (RS) em São Paulo, 2007. Para tal, amostras dos grupos de TLU e um grupo Controle de servidores ferroviários realizaram entrevistas, contagens sanguíneas, provas de atividade inflamatória, marcadores sorológicos de infecção e exame protoparasitológico de fezes. Ao término, foram avaliados 217 indivíduos. O grupo Controle relatou menor cobertura vacinal para o tétano, enquanto os Varredores tiveram a menor proporção de cobertura para a hepatite B. Os Motoristas usaram mais antibióticos e apresentaram o número de leucócitos mais elevado quando comparados aos Controles. Os Motoristas apresentaram também maiores médias de neutrófilos e monócitos quando comparados aos Varredores. A presença de parasitas nas fezes foi mais frequente entre os Varredores e os Coletores quando comparados aos Controles. Os grupos de Coleta, Transbordo e Aterro apresentaram indicadores de infecções respiratórias e de atividade inflamatória sistêmica similares aos Controles. Não foram observadas diferenças entre episódios de sinusites, pneumonias, marcadores séricos de atividade inflamatória, contato com o vírus da hepatite B ou com a estreptolisina O entre os grupos estudados. Palavras-chave: resíduos sólidos, saúde do trabalhador, exposição a agentes biológicos. AbstractThe purpose of this work was to evaluate the health effects due to biological exposure within different activities performed by groups of urban cleaning workers (UCW) compared to each other and to a control group of railway workers in Sao Paulo, 2007. Functional groups of UCW were submitted to interviews, blood counts, tests of inflammatory activity, serologic markers of infection, and stool parasitological testing. The final evaluation included 217 participants. The Control group reported lower vaccine protection against tetanus, whereas the Sweepers reported the lowest vaccine protection against hepatitis B. Drivers reported more antibiotic use and showed higher total leukocyte counts when compared to Controls. Drivers also demonstrated higher neutrophils and monocytes counts when compared to Sweepers. There was a higher presence of stool parasites among Sweepers and Collectors when compared to Controls. There were also no differences in indicators of respiratory infections or increased measurable inflammatory activity between Collectors, Landfills, and Intermediate Stations workers when compared to Controls. There were no differences in the number of sinusitis or pneumonias episodes, as well as serologic markers for inflammatory activity, contact with hepatitis B virus or anti-streptolysin O among studied groups.