The role of allergic rhinitis in nasal responses to sudden temperature changes

Background: A neuroallergic interaction was reported in the pathogenesis of allergic rhinitis (AR), but the pathophysiology of nonallergic rhinitis (NAR) is poorly understood. We aimed to explore the contribution of neuroallergic mechanisms to the pathogenesis of NAR. Methods: Subjects were divided into three groups – NAR patients (n = 25), AR patients (n = 16) and the control group (n = 10) – and were assessed using the nasal provocation test (NPT) with house dust mite. Total symptom scores, nasal inspiratory peak flow and nasal lavage were performed before and after NPT. Nasal brushing and scraping was done after NPT. Results: NPT was positive in NAR (52%) and AR (100%) patients and negative in all controls. After NPT, total symptom scores increased in both rhinitis groups. Post-NPT values of nasal inspiratory peak flow decreased only in AR patients. NAR patients showed a similar inflammatory cell profile in the nasal smears to AR patients which was different in controls. There were more tryptase- and immunoglobulin E (IgE)-positive cells in the nasal mucosa of AR patients, and more substance-p-positive cells were observed in NAR patients compared with controls. However, IgE- and tryptase-positive cells in NAR patients and substance-p-positive cells in AR patients were detectable in nasal mucosa, but rarely in the controls. Comparing the values before and after NPT, tryptase significantly increased in the nasal lavages of AR and NAR patients, while house dust mite-specific IgE did not change. Conclusions: We showed the existence of a common pathophysiological mechanism with different contributions in AR and NAR. We conclude that the difference in dominance of neuroallergic ways may determine the major phenotype of rhinitis.

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“…Previously, the nasal lavages were shown to make a difference between the rhinitis and healthy groups, but only in later phases [26]. …”

Section: Discussionmentioning

confidence: 99%

Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

Kavut

Kalpaklıoğlu

Atasoy

2012

Int Arch Allergy Immunol

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“…Physical and chemical factors can induce nasal symptoms which may mimic rhinitis in subjects with sensitive mucous membranes and even in normal subjects if the concentration of chemical triggers is high enough (173,174). Sudden changes in temperature can induce nasal symptoms in patients with allergic rhinitis (175). Chronic effects of cold dry air are important.…”

Section: Hormonal Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,826

1,761

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“…Low thermoregulation is possibly the main factor explaining the high morbidity among the elderly, as suggested by Graudenz et al (2006). It would be interesting for the future to assess the influence of some other factors, such as the socio-economic status or previous pathologies (O'Nell et al, 2003;Bateson and Schwartz, 2004;Jerrett et al, 2004;O'Nell et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

Influence of Meteorological Parameters and Air Pollutants onto the Morbidity due to Respiratory Diseases in Castilla-La Mancha, Spain

Monsalve

Tomás

Fraile

2013

Aerosol Air Qual. Res.

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This study considers the relationship between the risk of hospital admission due to respiratory diseases, the daily weather, and the air pollution conditions between 2000 and 2006. A synoptic climatological approach is used to investigate the links between weather types and all hospital admissions due to respiratory diseases in Castilla-La Mancha (CLM), Spain. The main circulation weather types (CWTs) were determined for winter and spring, the seasons with the highest percentage of hospital admissions, and the frequency distribution of these types was also analyzed. The study includes a summary of the main characteristics of the hospital admission series and their distribution over the study period of seven years, as well as the frequency distributions of the admissions classified by gender and age, for each season, month and day of the week. In addition, an admission index was used to compare CWTs and hospital admissions due to respiratory diseases. The results show distinctly different responses of daily respiratory disease admission rates (RD) to the eight CWTs identified in winter and in spring. In winter, three CWTs (southwesterly (SW), anticyclonic (A) and hybrid anticyclonic southwesterly (HASW)) present values 1.5 times above the average admission rates. In contrast, there are no significant differences in spring. Finally, the results of Principal Component Analysis applied to the daily series of meteorological parameters, atmospheric pollutants and morbidity data revealed that in winter the decrease in RD is related to increases in temperature and pressure. These results represent an important step in identifying reliable connections between weather-air pollutants and human health.

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The role of allergic rhinitis in nasal responses to sudden temperature changes

Cited by 122 publications

References 28 publications

Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Influence of Meteorological Parameters and Air Pollutants onto the Morbidity due to Respiratory Diseases in Castilla-La Mancha, Spain

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