Objetivou-se neste trabalho descrever uma malformação congênita observada em neonato canino atendido em um Hospital Veterinário Escola. O feto apresentava alterações macroscópicas de gastrosquise e toracosquise. Devido ao grande defeito anatômico observado no neonato canino do presente estudo e as escassas informações na literatura de como proceder com essas malformações congênitas na medicina veterinária bem como a falha no tratamento de suporte neonatal, optou-se pela eutanásia do feto. Por se tratar de uma malformação congênita, a gastrosquise e toracosquise apresentam tratamento limitado, sugerindo a necessidade de estudos sobre o desenvolvimento embrionário, a eficiência de técnicas cirúrgicas aplicáveis e tratamento de suporte neonatal adequado, a fim de garantir um bom prognóstico para os pacientes portadores.
The aim of this study was to assess systemic and neurotoxic changes following an epidural administration of meloxicamin to rabbits. Twelve adult rabbits four males and eight females; average mass, 1.9 ± 0.1kg were randomly divided into two groups: a control group (GC), which received a single dose of 0.9% NaCl epidurally in a volume of 0.3mL kg-1and a meloxicam group (GM), which received 0.2mg kg-1 meloxicam epidurally along with 0.9% NaCl in a total volume of 0.3mL kg-1. Heart rate, respiratory rate, body temperature, and neurological abnormalities were assessed prior to administration of anesthesia (H0), 1, 2, 3, 6, 12, and 24h following epidural puncture (H1, H2, H3, H6, H12, and H24, respectively), and every 24h afterward for 10 days after epidural puncture (D2, D3, D4, D5, D6, D7, D8, D9, and D10). The surface temperature of lumbosacral region was also measured at H0, H1, H6, H12, H24, D5 and D10. Three animals from each group were euthanized on days 15 and 30 after epidural puncture to assess possible spinal injuries. Variances observed in physiological parameters were not suggestive of adverse effects of meloxicam, as all were within the reference standards, and there were no physical or behavioral changes observed. Neurological function was similar between groups, with only difference between baseline values and values 1h after epidural administration in both groups. There were no histopathological changes in the GM group, and only one animal showed discrete lymphocytic infiltrate. Epidural lumbosacral administration of meloxicam at a dose of 0.2mg kg-1 caused no significant systemic or neurotoxic effects in rabbits.
We compared the analgesia and cardiopulmonary changes induced by epidural methadone or fentanyl in combination with lidocaine in female dogs undergoing elective ovariohysterectomy and anesthetized with propofol. Eighteen female dogs were randomly assigned to two groups and given either methadone (0.3 mg kg?¹) + 2% lidocaine without vasoconstrictor (LM) or fentanyl (5 µg kg?¹) + 2% lidocaine without vasoconstrictor (LF). The drugs were administered epidurally in a volume of 0.25 ml kg?¹. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic blood pressure (SBP), and blood glucose levels were recorded before and 15 minutes after premedication (T0 and T1); 15 minutes after epidural administration (T2); five minutes after dermotomy (T3); five minutes after clamping of the ovarian pedicle (T4); five minutes and 1, 3, 6, 12, 18, and 24 hours (T5, T6, T7, T8, T9, T10, and T11, respectively) after surgery. The number of additional propofol injections and total propofol dose (mg kg?¹) were recorded. Analgesia was assessed using a numerical descriptive scale. SBP and HR were similar in both groups, but hypotension was detected in animals from both groups at different times. Respiratory rate decreased significantly at T6 in the LF group and was lower than in the LM group. Hypothermia was observed in animals from both groups, but RT was significantly lower than baseline values only at T4 in the LM group. Blood glucose levels increased significantly only in the LF group at T4, T7, and T8. All animals in the LF group and eight animals in the LM group required additional propofol injections at T4, but no significant differences were detected in the number of propofol injections and total propofol dose between the LF (3 ± 1 injections, 7.5 ± 4.5 mg kg?¹) and LM (2 ± 2 injections, 4.5 ± 3.4 mg kg?¹) groups. The latency period, anesthetic period, and the duration of surgery were similar in both groups. No animals required rescue analgesia. The lidocaine-methadone and lidocaine-fentanyl combinations caused minimal cardiorespiratory changes, but did not abolish pain at the time of handling of the ovarian pedicle.
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