No abstract

RESUMENAntecedentes: En el embarazo se producen variaciones hormonales muy marcadas y estas se asocian con grandes modificaciones del perfil lipídico. Objetivos: Evaluar el perfil lipídico de mujeres adultas por trimestre de gestación y comparar el perfil lipídico de un grupo control de mujeres no embarazadas con gestantes del primer trimestre, que consultan al servicio de Maternidad del Hospital Público Provincial "Dr. Ramón Madariaga". Método: Se estudiaron 248 embarazadas, 69 en primer trimestre, 78 segundo y 101 tercero. Además un grupo control de 43 no gestantes con distribución etárea, índice de masa corporal y criterios de exclusión similares al grupo de gestantes. Se extrajo sangre con 12 horas de ayuno para las determinaciones bioquímicas, las cuales fueron realizadas por métodos enzimáticos colorimétricos, con controles de calidad interno y externo. Resultados: Se encontró que colesterol total, triglicéridos, col-VLDL, col-LDL, los índices colesterol total/col-HDL y triglicéridos/col-HDL, fueron aumentando significativamente en cada trimestre, mientras que el c-HDL no presentó diferencias. Los valores de percentilo 95 del tercer trimestre para CT de 321 mg/dl y TG 371 mg/dl, podrían ser utilizados como valores de corte en nuestra población. Cuando se comparó mujeres no gestantes versus embarazadas del primer trimestre no se encontraron cambios significativos. Conclusiones: El seguimiento del perfil lipídico de las gestantes podría convertirse en una herramienta diagnóstica que permita monitorear aumentos que superen lo considerado como fisiológico, llevando a un adecuado control prenatal. PALABRAS CLAVE: Riesgo aterogénico, embarazo, perfil lipídico SUMMARY Background:In pregnancy hormonal changes occur very marked and these are associated with major changes in the lipid profile. Aims: To evaluate the lipid profile of adult women during normal pregnancy in the first, second and third trimester and to compare the lipid profile of woman who are not pregnant with the lipid profile of woman who are in the first trimester of gestation and who are attended at the Maternity Public and Provincial Hospital "Dr. Ramón Madariaga". Methods: 248 pregnant women were evaluated of which: 69 women were in the first trimester; 78 women were in the second trimester and 101 women were in the third trimester. In addition a control group of 43 non-pregnant women with age distribution, body mass index and exclusion criteria similar to the group of pregnant women. Blood was extracted after twelve hours fasting to get the biochemical determinations which results were gotten by enzymatic colorimetric methods, with internal and external quality control. Results: It was found that total cholesterol; triglycerides, very low density and low density lipoprotein, the total cholesterol index/ high density lipoprotein y triglycerides/ high

In the city of Posadas, some 1 400 students suffer from metabolic syndrome and about 13 000 have at least one metabolic syndrome component. Joint efforts by the state government and the community are needed to change dietary habits and increase physical activity, mainly among boys, those 15-20 years of age, and the obese, to reverse the situation and reduce the morbidity/mortality that results from metabolic syndrome.

Thyroid dysfunctions are a cause of morbidity and disability worldwide. Little information has been found on the prevalence of thyroid dysfunctions in Paraguay, so this study provides data on their presentation. The objective was to determine the prevalence of thyroid dysfunction and its relationship with the lipid profile in adult outpatients attending the laboratory of the Regional Hospital of Encarnación, during January-November 2016. A descriptive cross-sectional study was performed, based on the review of 250 medical records, 84 % of whom were women; the median age was 39 (35-47) years in men and 36 (32-43) years in women. Thirty percent were hypothyroid and 3 % hyperthyroid; the most frequent thyroid dysfunction was subclinical hypothyroidism with 19 %. Highly significant differences were found for total cholesterol, LDL, VLDL and thyrotrophin between hypothyroid vs euthyroid, with the former having more atherogenic profiles. Logistic regression was used to assess the contribution of dyslipidaemia, finding a significant association with hypothyroidism (OR=3.24(1.81-5.81), p<0.001). Thirty-three percent of this population sample, 1 in 3 individuals, had thyroid dysfunction. These could be managed appropriately and further complications could be avoided.