Adiponectin and waist circumference as predictors of insulin-resistance in women

Bonneau, Graciela Alicia; Pedrozo, Williams; Berg, Gabriela

doi:10.1016/j.dsx.2013.10.005

Cited by 30 publications

(22 citation statements)

References 35 publications

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“…Furthermore, a most recent and up‐to‐date cohort study in 2014 carried out by Yamamoto Sin Japan suggested that higher levels of circulating adiponectin are associated with a lower risk of type 2 diabetes, and that adiponectin could confer a benefit in both persons with and without prediabetes. The same results were shown in other studies. In addition, several case–control studies by Pauer et al .…”

Section: Discussionsupporting

confidence: 60%

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Lai

Lin

Xing

et al. 2015

J of Diabetes Invest

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Aims/IntroductionAdiponectin has been proposed to have an essential role in the regulation of insulin sensitivity and metabolism, but previous studies on levels of adiponectin in prediabetes remain inconsistent. The present study aimed to assess the differences of adiponectin levels between prediabetes patients and healthy controls by carrying out a meta-analysis.Materials and MethodsWe carried out a systematic literature search of PubMed, EMBASE, and other databases for case–control studies and cohort studies measuring adiponectin levels in serum or plasma from prediabetes patients and healthy controls. The pooled weighted mean difference (WMD) and 95% confidence interval (CI) were used to estimate the association between adiponectin levels and prediabetes.ResultsThree cohort studies and 15 case–control studies with a total of 41,841 participants were included in the meta-analysis. The results showed that circulating adiponectin levels in prediabetes patients were significantly lower than that of healthy controls (WMD –1.694 μg/mL; 95% CI –2.151, –1.237; P < 0.001). Subgroup analysis showed more significant differences between prediabetes patients and healthy controls when the ratio of the homeostatic model assessment of insulin resistance was >2.12 (WMD −2.95 μg/mL; 95% CI –4.103, –1.806; P < 0.001) and average age was >60 years (WMD −2.20 μg/mL; 95% CI –3.207, –1.201; P < 0.001). Additionally, WMD in adiponectin showed a trend of direct correlation in subgroups of homeostatic model assessment of insulin resistance ratio, body mass index and age.ConclusionsThe present meta-analysis supports adiponectin levels in prediabetes patients being lower than that of healthy controls,indicating that the level of circulating adiponectin decreases before the onset of diabetes.

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Section: Discussionsupporting

confidence: 60%

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Lai

Lin

Xing

et al. 2015

J of Diabetes Invest

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“…Our regression analysis showed that in our population VAT was the most important determinant of HOMA-IR in accordance with previous research [48]. Other important determinants (Table 3) of HOMA-IR identified in our population were triglycerides and waist circumference, in line with other data [49][50][51][52][53][54]. Other parameters that were predictive for IR in this study cohort include HDL, serum creatinine, female gender, urine protein level, serum chloride, age, systolic blood pressure and estradiol.…”

Section: Discussionsupporting

confidence: 77%

Predictors of Insulin Resistance in Obesity and Type 2 Diabetes Mellitus - The Role of Magnesium

Milbouw¹,

Verhaegen²,

Verrijken³

et al. 2017

J Metabolic Synd

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Objectives: Hypomagnesaemia and insulin resistance are two major clinical problems, with intertwining pathophysiology. We aimed to explore this association in obese patients and in non-insulin-treated patients with type 2 diabetes mellitus (T2DM).Methods: Subjects were recruited from the outpatient diabetes/obesity clinic of the Antwerp University Hospital. The population (N=2731) consists of 2 subject groups with different degrees of insulin resistance and insulin secretory potential: 1) overweight (Body Mass index (BMI) ≥ 25 kg/m² and <30 kg/m²) and obese (BMI ≥ 30 kg/m²) subjects, 2) adult T2DM patients. Hypomagnesaemia was defined as serum magnesium <1.7 mg/dl. Insulin resistance was estimated using the Homeostasis model assessment (HOMA-IR; cut-off point 2.82).Results: Hypomagnesaemia was present in 6.1% of the entire population. Patients with hypomagnesaemia had more visceral adipose tissue (VAT), and a higher HOMA-IR. They suffered more from the metabolic syndrome and T2DM. Patients with a HOMA-IR<2.82 were younger, had lower BMI and less VAT. They suffered less from hypomagnesaemia. Hypomagnesaemia was more prevalent in T2DM patients than in obese subjects without T2DM. Although serum magnesium and HOMA-IR were negatively correlated, logistic regression analysis showed that magnesium was not a significant predictor for HOMA-IR. Conclusions:Despite a significant negative correlation between magnesium and HOMA-IR, magnesium was not retained as a significant determinant of insulin resistance compared to the other predictors in our population of obese subjects and T2DM patients.

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“…Insulin sensitivity is inversely associated with abdominal fat mass in nonpregnant women (48), and lower insulin sensitivity before pregnancy is related to less fat accumulation early in pregnancy (49). Therefore, insulin resistance might explain part of our association between maternal abdominal fat mass and GWG.…”

Section: Discussionmentioning

confidence: 95%

Maternal prepregnancy waist circumference and BMI in relation to gestational weight gain and breastfeeding behavior: the CARDIA study

Kirkegaard¹,

Nøhr

Rasmussen

et al. 2015

The American Journal of Clinical Nutrition

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Adiponectin and waist circumference as predictors of insulin-resistance in women

Cited by 30 publications

References 35 publications

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Predictors of Insulin Resistance in Obesity and Type 2 Diabetes Mellitus - The Role of Magnesium

Maternal prepregnancy waist circumference and BMI in relation to gestational weight gain and breastfeeding behavior: the CARDIA study

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