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We measured coherence between the electroencephalogram at different scalp sites while human subjects performed delayed response tasks. The tasks required the retention of either verbalizable strings of characters or abstract line drawings. In both types of tasks, a significant enhancement in coherence in the range (4-7 Hz) was found between prefrontal and posterior electrodes during 4-s retention intervals. During 6-s perception intervals, far fewer increases in coherence were found. Also in other frequency bands, coherence increased; however, the patterns of enhancement made a relevance for working memory processes seem unlikely. Our results suggest that working memory involves synchronization between prefrontal and posterior association cortex by phase-locked, low frequency (4-7 Hz) brain activity.

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The results of studies intended to replicate the enhancement of spatial-temporal reasoning following exposure to 10 min. of Mozart's Sonata for Two Pianos in D Major (K.448) have been varied. While some studies have replicated the effect, others have not. We suggest that researchers' diverse choice of dependent measures may account for these varied results. This paper provides a neurophysiological context for the enhancement and considers theoretical and experimental factors, including the choice of dependent measures, the presentation order of the conditions, the selection of the musical composition, and the inclusion of a distractor task, that may contribute to the various findings. More work is needed before practical applications can be derived.

The "Mozart Effect," using the Piano Sonata in D Major (K.448), was examined in patients with seizures. In 23 of 29 instances significant decreases in epileptiform activity were noted from patients even in coma, with status epilepticus or with periodic lateralized epileptiform discharges (PLEDs). The effect may be immediate or require 40-300 sec to manifest itself. The change in the amount of ictal activity in one patient in coma was from 62% before the music to 21% during Mozart. Amplitudes of these discharges also have often decreased. Examples of PLEDs on both temporal areas are shown in which the effect was only on the left temporal area but in other patients only on the right temporal area. Brain maps during the music showed theta and alpha activity decreased on the central areas, while delta waves increased on the frontal midline area. The basis of this effect is likely that the superorganization of the cerebral cortex with its highly structured radial columns seen throughout both hemispheres may resonate with the superior architecture of Mozart's music.

The theoretical possiblity that strange matter is more stable than nuclear matter has enormous implications. It has been suggested to search for the possible formation of metastable strange matter with a relatively small baryon number A , S drops, in present fixed-target relativistic heavy-ion collisions at BNL and CERN. In this paper we estimate the sensitivity required for the above experiments to be successful. These estimates of the production (and lifetimes) of S drops as a function of A, strangeness S, and electric charge, Z, should be useful in designing and evaluating searches for S drops, ' A Z . For example, the production estimates for metastable S drops with A 5 30 indicate that they could be detected with dedicated experiments having high sensitivity. Furthermore, specific searches for metastable S drops with Z < 0 would have the advantage of a low intrinsic background. PACS number(s): 12.38. Mh, 12.40.Aa, 25.70.N~