Synchronization between prefrontal and posterior association cortex during human working memory

Sarnthein, Johannes; Petsche, H.; Rappelsberger, Peter; Shaw, Gordon L.; Stein, Astrid von

doi:10.1073/pnas.95.12.7092

Cited by 651 publications

(499 citation statements)

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“…Up till know electrophysiological studies compared only resting state with memory retention period characteristics. According to these results decreased interactions between the entire fronto-temporo-parietal networks were found during the resting state compared to WM tasks (Sarnthein et al, 1998;Sederberg et al, 2003;Sauseng et al, 2005; for review see Klimesch et al, 2008). Contrary to the above, the present results indicate that maintenance of visual information in WM enhances thetasynchrony within the frontal and between the fronto-temporal cortices while attentional functions required by both WM and oddball tasks may be supported by the same fronto parieto-occipital theta phase synchrony.…”

Section: The Potential Role Of Fm Theta Fc During Maintenance In Wmcontrasting

confidence: 71%

“…Maintenance of visual information in WM enhances theta-synchrony between frontal and temporo-parietal as well as between occipito-temporal regions (Sarnthein et al, 1998;Sederberg et al, 2003;Sauseng et al, 2005; for review see Klimesch et al, 2008). Decreased interactions between fronto-temporo-parietal networks was found during resting state and perception (Sarnthein et al, 1998) compared during WM tasks. Increasing the number of items to be retained was of the frontal cortex on the activation level of higher-order sensory areas (posterior association cortex, where sensory information is thought to be stored).…”

Section: Introductionmentioning

confidence: 97%

“…By establishing sustained coordinated timing of neuronal firing between distant cortical areas oscillatory synchronization integrates anatomically distributed processing and facilitates neuronal communication, thus for instance has a central role in input selection and synaptic plasticity (Fell & Axmacher, 2011). Maintenance of visual information in WM enhances theta-synchrony between frontal and temporo-parietal as well as between occipito-temporal regions (Sarnthein et al, 1998;Sederberg et al, 2003;Sauseng et al, 2005; for review see Klimesch et al, 2008). Decreased interactions between fronto-temporo-parietal networks was found during resting state and perception (Sarnthein et al, 1998) compared during WM tasks.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Frontal midline theta connectivity is related to efficiency of WM maintenance and is affected by aging

Tóth

Kardos

File

et al. 2014

Neurobiology of Learning and Memory

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Please cite this article as: Tóth, B., Kardos, Z., File, B., Boha, R., Stam, C.J., Molnár, M., Frontal midline theta connectivity is related to efficiency of WM maintenance and is affected by aging, Neurobiology of Learning and Memory (2014), doi: http://dx.doi.org/10. 1016/j.nlm.2014.04.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractRepresentations in working memory (WM) are temporary, but can be refreshed for longer periods of time through maintenance mechanisms, thereby establishing their availability for subsequent memory tests. Frontal brain regions supporting WM maintenance operations undergo anatomical and functional changes with advancing age, leading to age related decline of memory functions. The present study focused on age-related functional connectivity changes of the frontal midline (FM) cortex in the theta band (4-8 Hz), related to 2 WM maintenance. In the visual delayed-match-to-sample WM task young (18-26 years, N=20) and elderly (60-71 years N=16) adults had to memorize sample stimuli consisting of 3 or 5 items while 33 channel EEG recording was performed. The phase lag index was used to quantify connectivity strength between cortical regions. The low and high memory demanding WM maintenance periods were classified based on whether they were successfully maintained (remembered) or unsuccessfully maintained (unrecognized later). In the elderly reduced connectivity strength of FM brain region and decreased performance were observed. The connectivity strength between FM and posterior sensory cortices was shown to be sensitive to both increased memory demands and memory performance regardless of age. The coupling of frontal regions (midline and lateral) and FM-temporal cortices characterized successfully maintained trials and declined with advancing age. The findings provide evidence that a FM neural circuit of theta oscillations that serves a possible basis of active maintenance process is especially vulnerable to aging.

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Section: The Potential Role Of Fm Theta Fc During Maintenance In Wmcontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frontal midline theta connectivity is related to efficiency of WM maintenance and is affected by aging

Tóth

Kardos

File

et al. 2014

Neurobiology of Learning and Memory

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“…Similarly, Engel and Singer (2001) support the hypothesis that neural synchrony within millisecond precision may be implicated in arousal, perceptual integration, attentional selection and WM. Hence temporal dynamics within neuronal populations seems to be critical for the functioning of WM (Tallon-Baudry, Bertrand, Peronet, & Pernier, 1998;Sarnthein, Petsche, Rappelsberger, Shaw, & Stein, 1998;Engel & Singer, 2001). …”

Section: Moving Away From the Sub-component Paradigmmentioning

confidence: 99%

Dynamics of brain activity underlying working memory for music in a naturalistic condition

Burunat

Alluri

Toiviainen

et al. 2014

Cortex

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Sivumäärä -Number of pages 70Tiivistelmä -Abstract Working memory (WM) is at the core of any cognitive function as it is necessary for the integration of information over time. Despite WM's critical role in high-level cognitive functions, its implementation in the neural tissue is poorly understood. Preliminary studies on auditory WM show differences between linguistic and musical memory, leading to the speculation of specific neural networks encoding memory for music. Moreover, in neuroscience WM has not been studied in naturalistic listening conditions but rather in artificial settings (e.g., n-back and Sternberg tasks). Western tonal music provides naturally occurring motivic repetition and variation, recognizable units serving as WM trigger, thus allowing us to study the phenomenon of motif-tracking in the context of real music. Adopting a modern tango as stimulus, behavioural methods were used to identify the stimulus motifs and build a time-course predictor of WM neural responses. This predictor was then correlated with the participants' functional magnetic resonance imaging (fMRI) signal obtained during a continuous listening condition. Neural correlates related to the sensory processing of a set of musical features were filtered out from the brain responses to music to aid in the exclusive recruitment of executive processes of music-related WM. Correlational analysis revealed a widely distributed network of cortical and subcortical areas, predominantly right-lateralized, responding to the WM condition, including ventral and dorsal areas in the prefrontal cortex, basal ganglia, and limbic areas. Significant subcortical processing areas, active in response to the WM condition, were pruned with the removal of the acoustic content, suggesting these music-related perceptual processing areas might aid in the encoding and retrieval of WM. The pattern of dispersed neural activity indicates WM to emerge coherently from the integration of distributed neural activity spread out over different brain subsystems (motoric-, cognitive-and sensory-related areas of the brain).Asiasanat -Keywords working memory; cognitive neuroscience; music; musical motifs; functional magnetic resonance imaging ( Lashley was attempting to identify the locus of memory within the cortex, and, to do so, first trained rats to run mazes, and then removed various cortical regions. He allowed the animals to recover and tested the retention of the maze-running skills. To his surprise it was not possible to find a particular region corresponding to the ability to remember the way through a maze. Instead all the rats which had had cortex regions removed suffered some kind of impairment, and the extent of the impairment was roughly proportional to the amount of cortex taken off. Removing cortex damaged the motor and sensory capacities of the animals, and they would limp, hop, roll, or stagger, but somehow they always managed to traverse the maze. So far as memory 'as concerned, the cortex appeared to be equipotential, that is, with all regions of eq...

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“…Reduced GABAergic inhibition, in turn, leads to reduced synchrony of firing of groups of pyramidal neurons (Hajos et al 2008;Hajos et al 2000). Such synchrony is thought to be necessary for a variety of cognitive functions (Miltner et al 1999;Sarnthein et al 1998;Soltesz and Staley 2006;Varela et al 2001), and its demonstrated deficiency in schizophrenia has been proposed as an underlying cause of cognitive deficits and psychosis in this disorder (Benes and Berretta 2001;Ford et al 2007;Uhlhaas and Singer 2010). Regular cannabis use in otherwise healthy individuals is also associated with neural synchrony deficits, whose magnitude is correlated with levels of schizotypal personality traits, which qualitatively resemble schizophrenia symptoms (Skosnik et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study

et al. 2012

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Rationale-Frequent cannabis use is a risk marker for schizophrenia and delusions, but the neurocognitive mechanisms of this relationship remain unclear.Objectives-We sought evidence that cannabis users have deficits in processing relationships between meaningful stimuli, similar to abnormalities reported in schizophrenia, and that these deficits are associated with delusion-like ideation. We used the N400 event-related brain potential (ERP) waveform as a neurophysiological probe of activation of concepts in semantic memory. We hypothesized that cannabis users would exhibit larger (more negative) than normal N400 amplitudes in response to stimuli meaningfully related to a preceding prime-reflecting deficient activation of concepts related to the prime. We further hypothesized that the magnitude of this abnormality would correlate with severity of delusion-like ideation.Methods-We recorded ERPs in 24 frequent cannabis users and 24 non-using comparison participants who viewed prime words followed by targets which were either words related or unrelated to the prime or pronounceable non-words. The participants' task was to indicate whether the target was a word. Delusion-like ideation was measured via the Schizotypal Personality Questionnaire.Results-Contrary to our hypothesis, cannabis users exhibited smaller than normal N400s to both related and unrelated targets. These abnormalities correlated with delusion-like ideation in cannabis users only. Conclusions-The results are consistent with a generalized abnormality of activation within semantic memory neural networks in cannabis users. Further research is needed to investigate whether such an abnormality plays a role in the development of delusion-like ideation in cannabis users.

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Synchronization between prefrontal and posterior association cortex during human working memory

Cited by 651 publications

References 31 publications

Frontal midline theta connectivity is related to efficiency of WM maintenance and is affected by aging

Frontal midline theta connectivity is related to efficiency of WM maintenance and is affected by aging

Dynamics of brain activity underlying working memory for music in a naturalistic condition

Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study

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