Triazole and imidazole are incorporated into the structures of many antifungal compounds. In this study a novel series of 1,2,4-triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome P450 14α-demethylase (14DM). These structures were docked into the active site of MT-CYP51, using Autodock program. Sixteen compounds with the best binding energy were synthesized. The chemical structures of the new compounds were confirmed by elemental and spectral ((1) H-NMR and Mass) analyses. All compounds were investigated for antifungal activity against Candida albicans, Candida tropicalis, Candida glabrata, Candida parapeilosis, Candida kruzei, Candida dubliniensis, Aspergillus fomigatus, Aspergillus flavus, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophyte, Epidermophyton floccosum. Some compounds showed excellent in-vitro antifungal activity against most of the tested fungi. Compounds 2, 9, and 10 had antifungal activity against several resistant fungi against fluconazole and itraconazole.
Phenol is a known prejudicial exotoxin and fi nds place in the environment due to intense activity of petrol industry. The aim of this applied-analytical study is to investigate phenol removal from urban drinking water using batch reactor with using powdered eggshell. Various operating variables are tested for their effects on phenol removal; these include pH, contact time, adsorbent doses, initial phenol concentration, reaction kinetics, and powdered eggshell characteristics. Sample of urban drinking water is prepared containing 5-15 mg/L phenol. Powdered eggshell is prepared in a laboratory oven at 105˚C for 12 h. The phenol-containing water enters batch reactor and phenol removal effi ciency is studied in different cases of the variables pH (3-11), contact time (0-120 min), and adsorbent doses (3-5 gr/dl). Characteristics of the eggshell powder show that the average diameter size of eggshell powder is 2 μm. The main component of eggshell powder is calcium carbonate (CaCO 3). The best conditions for phenol removal are obtained to be pH 3, contact time 80 min, and adsorbent dose 4 gr, and phenol concentration 5 mg/L. The adsorption of phenol on powdered eggshell is obtained from Langmuir isotherm.
Poly aromatic hydrocarbons (PAHS) and total petroleum hydrocarbon (TPH) on receiving water were a major concern in many country of the world specially producer of oil and related petrochemical products. Such pollutants often had an effect on aquatic environment and on human health. The removal of PAHS and TPH from one of Iran's petrochemical effluent by using of a Bio-Enzyme mixture had been studied at laboratory scale. The investigation review Biochemical characterization of the sample in contact with application of bio-enzyme, by installing of batch reactor (with and without application said bio-enzyme). The batch reactor runs for 10 days and result shown that without presence of said bio-enzyme PAHS, TPH, and chemical oxygen demand (COD) did not remove and there is not any changes after 10 days , even the batch reactor by apply of a mixture of bio-enzyme removed TPH /PAH, and COD about 99.98%, and 100% after 10 days, respectively.Main factors that manage the removal process were the bio-enzyme activity in hydrolysis and oxidation of pollutants. As a result, the Bio-enzymes activity and the mineralization of pollutants due to presence of millions of net micro-Bio-enzymes were responsible for the removal TPH/PAH/COD. Index Terms-Bio-enzyme, chemical oxygen demand, poly aromatic hydrocarbons (PAH), total petroleum hydrocarbon, (TPH). Maryam Najafi member of board of biotechnology of PANDAB TADBIR ENGINEERING CO , MS in Environmental Engineering from TARBIAT MODDARESS UNIVERSITY OF TEHRAN, 1994, she is expert in water and waste water treatment , familiar with process arrangement , process selection , design and optimization of existing plant by application of a series of modification by using of new technology focus on bio-Enzyme application, Ms.M.Najafi is a member of APCBEES and the Giti Haji Mohammad hossien kashi. Member of
Groundwater is a basic source of drinking water supply for urban and rural areas. This is especially the case for communities located in arid and semi‐arid regions that rely on groundwater for drinking purposes. The present study set out to assess the potential health impacts of water impurities and to investigate the qualitative status of drinking water in Robat Karim rural areas, located in southwest Tehran, Iran. A total of 66 samples were collected from the water distribution network of 11 villages (33 sampling points, on two occasions) during September 2020 and were tested in terms of the most common quality parameters such as pH, mercury (Hg), lead (Pb), copper (Cu), zinc (Zn), chloride (Cl–), chlorate (ClO3–), nitrite (NO2–), nitrate (NO3–), and flouride (F–). Multiple methods and indexes including water quality index (WQI), hazard quotient (HQ), and hazard index (HI), were worked out to assess the quality of water and health risk assessment of NO3– Pb2+ and Hg2+. The results revealed that 33% and 90% of sampling sites have significantly high nitrate and total hardness (TH) concentrations, exceeding the maximum permissible limits set by World Health Organization (WHO; 50 and 200 mg/L, respectively). Furthermore, five sampling points exhibited poor WQIs mainly related to NO3– and TH. HQ values higher than 1 for nitrate were noticed in most sampling locations. Except for one sampling point, the HQ obtained for Pb2+ and Hg2+ were below 1 indicating no obvious health hazard. This study represents that children and infants are at higher risk of chronic toxicity by excess NO3– intake. The health hazard that is yet imposed on the community by NO3– necessitates regular monitoring of drinking water, the use of advanced technologies to purify water or otherwise alternative resources should be proposed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.