Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus and is able to spread rapidly in humans. Preventive behavior is important for every individual to maintain their health during the COVID-19 pandemic. This study aims to determine the relationship between social support (family, friends, health workers), perceptions of the response to COVID-19, and exposure to social media for COVID-19 prevention behavior. This cross-sectional study was conducted in the Jabodetabek area in May 2020 with a voluntary sampling technique. The participants were 424 respondents. The proportion of respondents with good COVID-19 prevention behavior was 45.2%. The results of the multivariate analysis showed family support (OR = 2.736; 95% CI = 1.654 - 4.517), peer support (OR = 2.035; 95% CI = 1.205 - 3,436), support from health professionals (OR = 1.729; 95% CI = 1.023 - 2,923); and sources of information regarding COVID-19 (OR = 1,692; 95% CI = 1,036 - 2,764) had a significant relationship with COVID-19 prevention behavior (P <0.05). It can be concluded that family support has dominant influence on COVID-19 prevention behavior in Jabodetabek community. For this reason, social support from the smallest scale (family) and reliable sources of information related to COVID-19 are needed so that community can implement COVID-19 prevention behavior properly in daily life. Abstrak Coronavirus disease 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh virus SARS- CoV-2 dan mampu menyebar dengan cepat pada manusia. Perilaku pencegahan penting dilakukan oleh setiap individu demi menjaga kesehatannya di masa pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui hubungan dukungan sosial (keluarga, teman, dan tenaga kesehatan), persepsi penanggulangan COVID-19, dan keterpaparan terhadap media sosial terhadap perilaku pencegahan COVID-19. Penelitian cross-sectional dilakukan pada bulan Mei 2020 di wilayah Jabodetabek dengan teknik voluntary sampling. Responden berjumlah 424 responden. Proporsi responden dengan perilaku pencegahan COVID-19 yang baik sebesar 45,2%. Hasil analisis multivariat menunjukkan dukungan keluarga (OR= 2,736; CI 95%= 1,654 - 4,517), dukungan teman (OR=2,035; CI 95%= 1,205 - 3,436), dukungan tenaga kesehatan (OR=1,729; CI 95%= 1,023 - 2,923); dan sumber informasi mengenai COVID-19 (OR= 1,692; CI 95%= 1,036 - 2,764) memiliki hubungan yang signifikan terhadap perilaku pencegahan COVID-19 (P<0,05). Dapat disimpulkan bahwa dukungan keluarga memiliki pengaruh dominan terhadap perilaku pencegahan COVID-19 pada masyarakat Jabodetabek. Oleh karena itu, dukungan sosial dari skala terkecil (keluarga) dan sumber informasi terpercaya sangat dibutuhkan agar masyarakat mampu menerapkan perilaku pencegahan COVID-19 dengan baik dalam kehidupan sehari-hari.
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