Gilton Marques dos Santos scite author profile

Gilton Marques dos Santos

25Publications

43Citation Statements Received

224Citation Statements Given

How they've been cited

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541

211

Affiliations

Federal University of Bahia, Hospital Ana Nery

Publications

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SOD1 Plasma Level as a Biomarker for Therapeutic Failure in Cutaneous Leishmaniasis

Khouri

Santos

Soares

et al. 2014

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We show that increased plasma superoxide dismutase 1 (SOD1) levels are statistically significant predictors of the failure of pentavalent antimony treatment for cutaneous leishmaniasis caused by Leishmania braziliensis. In Leishmania amazonensis–infected patients, host SOD1 levels can be used to discriminate between localized and drug-resistant diffuse cutaneous leishmaniasis. Using in situ transcriptomics (nCounter), we demonstrate a significant positive correlation between host SOD1 and interferon α/β messenger RNA (mRNA) levels, as well as interkingdom correlation between host SOD1 and parasite SOD2/4 mRNA levels. In human macrophages, in vitro treatment with SOD1 increases the parasite burden and induces a diffuse cutaneous leishmaniasis–like morphology. Thus, SOD1 is a clinically relevant biomarker and a therapeutic target in both localized and diffuse cutaneous leishmaniasis.

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Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women

Ribeiro

Pereira

Santos

et al. 2019

Experimental Gerontology

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Conhecimento de pediatras sobre a atividade física na infância e adolescência

Gordia

Quadros

Silva

et al. 2015

Revista Paulista de Pediatria

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Objective:To investigate the knowledge and guidance given by pediatricians regarding physical activity in childhood and adolescence.Methods:A cross-sectional study involving a convenience sample of pediatricians (n=210) who participated in a national pediatrics congress in 2013. Sociodemographic and professional data and data regarding habitual physical activity and pediatricians’ knowledge and instructions for young people regarding physical activity were collected using a questionnaire. Absolute and relative frequencies and means and standard deviations were calculated.Results:Most pediatricians were females, had graduated from medical school more than 15 years ago, and had residency in pediatrics. More than 70% of the participants reported to include physical activity guidance in their prescriptions. On the other hand, approximately two-thirds of the pediatricians incorrectly reported that children should not work out and less than 15% answered the question about physical activity barriers correctly. With respect to the two questions about physical activity to tackle obesity, incorrect answers were marked by more than 50% of the pediatricians. Most participants incorrectly reported that 30 min should be the minimum daily time of physical activity in young people. Less than 40% of the pediatricians correctly indicated the maximum time young people should spend in front of a screen.Conclusions:In general, the pediatricians reported that they recommend physical activity to their young patients, but specific knowledge of this topic was limited. Programs providing adequate information are needed.

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Nutritional impact of inflammatory bowel diseases on children and adolescents

Santos¹,

Silva²,

Santana³

2014

Rev. paul. pediatr.

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There are nutritional consequences of inflammatory bowel diseases in children and adolescents, mainly growth stunting, slower pubertal development, underweight and vitamin deficiencies. Nutritional impairments were more significant in patients with Crohn's disease; overweight and obesity were more common in patients with ulcerative rectocolitis. A detailed nutritional assessment should be performed periodically in children and adolescents with inflammatory bowel disease.

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The Knowledge and Participation of the Father in Breast Feeding, Salvador, Brazil

Lima¹,

Santana²,

Santos³

et al. 2016

OJOG

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The most fundamental influence in the breastfeeding process is the father's support. The mother feels safer in breastfeeding when she has her partner's support and a more active and effective participation. This study aimed at evaluating the father's knowledge about breastfeeding in a quantitative approach through a transversal cohort study, interviewing 78 fathers in a public maternity in Salvador. The average age of the interviewees was 29.9 years and 53.8% had an incomplete fundamental schooling. Regarding knowledge of the subject, 10.3% believed that breastfeeding can be substituted. All fathers interviewed answered that they support breastfeeding for their children and believe in its benefits; 39.7% reported that their opinion could interfere their partner's decision to prolong the process. Moreover, 69.2% of the males attended their partner's antenatal meetings, and of these, over a third had no intervention on the subject. Of all the participants, 80.8% confirmed that they had participated in the breastfeeding process and emphasized their gratification during this phase. About the paternal opinion, 39.7% believed that there is a degree of influence over the partner's decision to breastfeed, and for that reason 50% told the mother their opinion. The study widened the knowledge about the role of the father in breastfeeding, ratifying the importance of their support towards the mother in this process, ultimately contributing to improving the practice and benefiting the mother-child relationship. Therefore, we conclude that those interviewed have some knowledge about breastfeeding, recognize its importance during the process and would like to know more.

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Avaliação nutricional de crianças internadas em hospital publico e hospital particular, e de suas mães, em Salvador, Bahia

Ribeiro¹,

Silva²,

Kachimareck³

et al. 2015

cmbio

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Introdução: A avaliação nutricional é um eficiente indicador das condições gerais de saúde da criança, especialmente durante a hospitalização. Entretanto, ela é pouco relatada na literatura. Objetivo: Avaliar o estado nutricional de crianças internadas em um hospital público e um hospital particular na Bahia. Metodologia: Trata-se de um estudo tipo coorte transversal, pelo qual foram avaliados os Índices de Massa Corporal (IMC) de 100 crianças internadas em um hospital público e 77 em um hospital particular, bem como de suas respectivas mães, no dia da admissão, entre Junho e Agosto de 2013. Foi utilizada a curva de crescimento Idade x IMC (z-score). Resultados: Das 177 crianças, 65 apresentaram IMC alterado, quatro delas com magreza acentuada, 12, magreza, 24 apresentaram risco de sobrepeso, 19 tinham sobrepeso e seis eram obesas. O risco de sobrepeso e sobrepeso foram as alterações mais frequentes no hospital público e o risco de sobrepeso, a mais frequente no hospital particular. Total de 56,3% das crianças acima do peso apresentaram mães igualmente acima do peso, enquanto que a concordância de eutrofia entre filhos e suas mães foi de 58,9%. Conclusão: Risco de sobrepeso foi a alteração mais frequente, no geral, o que está de acordo com a atual situação de transição nutricional do país. Parece haver associação entre estado nutricional da criança e das suas mães. Há necessidade deavaliação nutricional sistemática em todas as crianças hospitalizadas.

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Knowledge of pediatricians regarding physical activity in childhood and adolescence

Gordia

Quadros

Silva

et al. 2015

Revista Paulista de Pediatria (English Edition)

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Repercussões nutricionais em crianças e adolescentes na presença de doenças inflamatórias intestinais1

Santos

Silva

Santana

2014

Revista Paulista de Pediatria

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OBJECTIVE: To perform a sistematiy review of the literature about the nutritional impact of inflammatory bowel diseases in children and adolescents. DATA SOURCES: A systematic review was performed using PubMed/MEDLINE, LILACS and SciELO databases, with inclusion of articles in Portuguese and in English with original data, that analyzed nutritional aspects of inflammatory bowel diseases in children and adolescents. The initial search used the terms "inflammatory bowel diseases" and "children" or "adolescents" and "nutritional evaluation" or "nutrition deficiency". The selection of studies was initially performed by reading the titles and abstracts. Review studies and those withouth data for pediatric patients were excluded. Subsequently, the full reading of the articles considered relevant was performed. RESULTS: 237 studies were identified, and 12 of them were selected according to the inclusion criteria. None of them was performed in South America. During the analysis of the studies, it was observed that nutritional characteristics of patients with inflammatory bowel disease may be altered; the main reports were related to malnutrition, growth stunting, delayed puberty and vitamin D deficiency. CONCLUSION: There are nutritional consequences of inflammatory bowel diseases in children and adolescents, mainly growth stunting, slower pubertal development, underweight and vitamin deficiencies. Nutritional impairments were more significant in patients with Crohn's disease; overweight and obesity were more common in patients with ulcerative rectocolitis. A detailed nutritional assessment should be performed periodically in children and adolescents with inflammatory bowel disease.

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