Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women

Ribeiro, Israel Souza; Pereira, Ítalo Sousa; Santos, Denisar Palmito dos; Lopes, Danilo N.; Prado, Alice O.; Calado, Stefano Pedro de Melo; Gonçalves, Caroline Vieira; Galantini, Maria Poliana Leite; Muniz, Igor Pereira Ribeiro; Santos, Gilton Marques dos; Silva, Robson A.A.

doi:10.1016/j.exger.2019.110734

Cited by 18 publications

(21 citation statements)

References 83 publications

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“…Diabetic overweight and obese children were significantly 3.8 folds more at risk to be bad glycemic control than diabetic children with normal BMI. This result comes in line with that of El-Wakeel et al's study [42]; this strong association was confirmed by many other studies [8], [18].…”

Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 91%

“…Comparison of different variables in both obese and normal-weight groups according to BMI group revealed that serum cholesterol, IL-10, IL-17, HBA1c levels, and insulin dose are the factors showing a significant difference between both groups. And to some extent, the findings of previous researches came in accordance with our conclusion as the study done by Israel et al [8]. We next performed multiple linear regression analysis to predict variants that are independently associated with BMI and we found that IL-10 and IL-17 concentration are strongly associated with BMI.…”

Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 89%

“…Another important factor is the phenomena called inflammaging, which consists of the positive regulation of the chronic low-grade inflammatory. Thus, high levels of pro-inflammatory cytokines like IL-17 combined with the reduction of anti-inflammatory cytokines, like IL-10, lead to an imbalance in the inflammatory composition of the innate and acquired immune system and have been related to the development and maintenance of several chronic diseases like T1DM [8].…”

Section: Introductionmentioning

confidence: 99%

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Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Obesity is an expanded health problem worldwide and it is blamed for a startling rise in type 1 diabetes (T1DM), the interaction between obesity, autoimmune processes, and glucose homeostasis is a growing field of study. AIM: This study was undertaken to predict the role of the inflammatory cytokines (interleukin [IL]-17 and IL-10) as biomarkers in early screening for obesity and T1DM and to determine the relation of inflammatory cytokines with diabetic complications especially nephropathy. SUBJECTS AND METHODS: The target group consisted of 92 children with type 1 diabetes children who were diagnosed according to the criteria provided by American Diabetes Association Diabetic; cases were divided into two groups, Group 1 (overweight and obese diabetics) and Group 2 (normal weight diabetic children). The levels of serum IL-17 and IL-10 were assayed in these children by an enzyme-linked immunosorbent assay. Serum triglycerides (TG) and cholesterol levels were measured as well as urinary microalbumin level was estimated for detection of nephropathy. RESULTS: Diabetic overweight and obese children exhibited significantly 3.8 folds more at risk to be bad glycemic control than diabetic children with normal body mass index (BMI). Furthermore, overweight and obese diabetic children displayed significantly 15 times more at risk of having nephropathy than diabetic children with normal BMI. Low serum level of IL 10 and high level of IL 17 showed a significant association with high BMI in diabetic children. High HBA1c, low IL 10, and long disease duration were significantly considered as predominant risk factors for diabetic nephropathy in diabetic children. CONCLUSION: The obtained data from these investigations proved that overweight and obese children have a low serum level of IL-10 and high serum IL-17 levels. The relationship between IL-10/IL-17 can be applied as a good marker for the inflammatory state and these inflammatory interleukins can be employed as biomarkers in early screening for obesity and T1DM. Furthermore, these interleukins can be utilized as a predictor for early diabetic complications, particularly nephropathy.

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Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 91%

Section: Figure 2: Correlation Between Body Mass Index and Interleukisupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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“…Metabolic syndrome in the elderly 2021, Vol. 23, 2 2021 МС в среднем составляет 24% и характеризуется достоверными гендерными различиями, показывающими превышение в 2,4 раза распространенность среди женщин [13].…”

Section: метаболический синдром у пожилыхunclassified

“…Проведенные к настоящему времени клинические и эпидемиологические исследования по проблеме МС свидетельствуют о том, что рассматриваемая патология является возрастассоциированной и неуклонно повышается ее распространенность по мере старения населения, происходящего, прежде всего, в индустриальных странах [13]. Среди взрослого населения частота…”

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Informative significance of serum cytokines and their importance for development of metabolic syndrome with arterial hypertension in elderly persons

Agarkov¹,

Коломиец

Korneeva

et al. 2021

Med. immunol.

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Metabolic syndrome (MS) is among the main public health challenges worldwide, leading to significant labor losses, increased costs for treatment and rehabilitation of the patients. The aim of the present study was to identify the informative serum interleukins, by determining the odds ratio in elderly patients with MS and hypertension. The main group of 86 patients with MS and arterial hypertension (AH) aged 60-75 years was examined under clinical conditions. The inclusion criteria were as follows: age of 60-75 years, presence of MS, primary hypertension (grade II-III), absence of acute myocardial infarction, malignant neoplasms, disorders of cerebral circulation, kidney failure over last 6 months. Diagnostics of MS and hypertension was carried out in accordance with Expert Guidelines from the Russian Research Society of Cardiology on the MS Diagnosis and Treatment. Our first study of a large range of serum interleukins in elderly patients with MS and hypertension allowed us to reveal the inversely directed changes in pro- and anti-inflammatory cytokine contents. Combined AH/MS in elderly persons is accomplished by sufficient increase of the most proinflammatory cytokines, and vice versa, by significant decrease in anti-inflammatory cytokines in blood serum. This finding clearly points to importance of immunological regulatory systems for initiation of AH with MS at older age. Pro- and anti-inflammatory serum interleukins are actively involved into the AH/MS development in elderly accompanied by their pronounced imbalance. The mentioned immune reactions could underlie the MS/AH condition. High risk of this disorder is connected with changed production of proinflammatory cytokines (IL-8, IL-1β), like as anti-inflammatory serum interleukins (IL-4, IL-10), with predominance of the former. The above interleukins should be considered dominant diagnostic markers of AH/MS in elderly persons. Measurement of serum interleukins and discriminant-based approach allows highly reliable differentiation of elderly patients with AH/MS from similar individuals without this disorder.

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