In vitro and in vivo/SPECT imaging in SkBr3-bearing mice demonstrated that ¹¹¹ In-DOTA-trastuzumab is a potential compound for molecular imaging of SPECT for diagnosis and follow-up of HER2 expression in oncology.

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The TALYS code: TALYS is a computer code system Rhenium-186, having a half-life of 90.64 h, is an important radionuclide, used in metabolic radiotherapy and radio immunotherapy. 186 Re hydroxyethylidene diphosphonate (HEDP) is a new compound used for the palliation of painful skeletal metastases. Its production is achieved via charged-particle-induced reactions; the data are available in EXFOR library. For the work discussed in this paper, production of 186 Re was done via nat W(p,n) 186 Re nuclear reaction. Pellets of nat W were used as targets and were irradiated with 15, 17.5, 20, 22.5, 25 MeV proton beams at 5 µA current. The radiochemical separation was performed by the ion exchange chromatography method. The production yield achieved at 25 MeV was 1.91 MBq·µA -1 ·h -1 .Excitation functions for the 186 Re radionuclide, via 186 W(p,n) 186 Re and 186 W(d,2n) 186 Re reactions were calculated by ALICE-ASH and TALYS-1.0 codes to validate and fit the experimental data and to obtain a recommended set of data for 186 W(p,n) 186 Re reaction. Required thickness of the targets was obtained by SRIM code for each reaction.

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