Investigation of palladium-103 production and IR07-103Pd brachytherapy seed preparation

Saidi, Pooneh; Sadeghi, Mahdi; Enferadi, Milad; Aslani, Gholamreza

doi:10.1016/j.anucene.2011.06.018

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…The results were tabulated in Table 2. It can be seen that a very small difference exists between our reported normalized geometry function and the other similar work [22,25,28,30,31]. Additionally, radial dose function was tabulated in Table 3 which includes TLD measured and MCderived values for the same source of 103 Pd.…”

Section: Studymentioning

confidence: 79%

“…GNPs and other nanoparticles have been studied for their potential dose enhancement effect in brachytherapy [21][22][23]. In Monte Carlo (MC) studies, a newly fabricated 103 Pd source was investigated for its dosimetric property for application in brachytherapy of prostate cancer [24][25][26][27][28]. They confirmed its dosimetric suitability for brachytherapy of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

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A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Jangjoo

Ghiasi

Mesbahi

2019

Polish Journal of Medical Physics and Engineering

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103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

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Section: Studymentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Jangjoo

Ghiasi

Mesbahi

2019

Polish Journal of Medical Physics and Engineering

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“…Thus, the electrodeposition experiments were performed in acidic sulphate media using RhCl 3 .3H 2 O, Rh 2 (SO 4 ) 3 . The radiochemical processing of the irradiation targets involved (a) dissolution, (b) radiochemical separation of 103 -Pd from the Rh target solution and (c) recovery of 103 -Pd as the final product from the organic phases [22]. After the chemical separation process, 103 -Pd radioactive material is absorbed uniformly in the resin Amberlite IR-93 resin (20-50 mesh) bead to encapsulate inside the titanium capsule.…”

Section: -Pd Source Descriptionmentioning

confidence: 99%

Modelling, Simulation and Dosimetry of ¹⁰³-Pd Eye Plaque Brachytherapy

Saidi¹,

Sadeghi²

2019

Theory, Application, and Implementation of Monte Carlo Method in Science and Technology

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In this study, the dose distribution has been calculated for the Collaborative Ocular Melanoma Study (COMS) eye plaques at various diameters 10-22 mm, loaded with the 103-Pd brachytherapy seeds (Model IR06-103 Pd). Several Monte Carlo (MC) simulations have been employed to carry out the gold backing and Silastic insert effect on dose distribution around the eye plaque. Version 5 of the Monte Carlo N-particle (MCNP) code has been used to carry out the simulations. The new palladium seed was modelled in three geometric orientations (ideal, vertical and diagonal). Results are compared with the calculated data for COMS eye plaque loaded with Theragenics model 200 and Best model 2335 palladium-103 seeds and model 6711 iodine-125 seeds. The calculated dose rate constant of the IR06-103 Pd seed was found to be 0.692 AE 0.020 cGy h À1 U À1. The air kerma strength to deliver 85 Gy to tumour apex in a water medium was found to be 4.10 U/seed. The dosimetric parameters calculated in this work for the new palladium seed indicate the IR06-103 Pd seed is suitable for use in brachytherapy. In COMS plaques, the dose distribution to points of interest was compared for three 103-Pd seed models. With the exception of sclera dose and for a given prescription dose, the IR06 seed delivers lower dose ocular points of interest.

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“…• Low-dose-rate sources (LDR): Less than 2 Gy/h radioisotopes with low-energy photon emitters like 103 Pd and 125 I are used. Table 1 shows examples of radioisotopes commonly used in brachytherapy for the three mentioned categories [10].…”

Section: Introductionmentioning

confidence: 99%

“…Excitation function of 103 Rh(d,2n) 103 Pd reaction by ALICE/91, ALICE/ASH and TALYS-1.2 codes, and experimental data[10].…”

mentioning

confidence: 99%

Production of the ¹⁰³Pd via Cyclotron and Preparation of the Brachytherapy Seed

Saidi¹,

Sadeghi²

2020

Recent Techniques and Applications in Ionizing Radiation Research

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This study will briefly explain the production of 103 Pd via cyclotron for brachytherapy use. The excitation functions of 103 Rh(p,n) 103 Pd and 103 Rh(d,2n) 103 Pd reactions were calculated using ALICE/91, ALICE/ASH, and TALYS-1.2 codes and compared with published data. Production of 103 Pd was done via 103 Rh(p,n) 103 Pd nuclear reaction. The target was bombarded with 18 MeV protons at 200 μA beam current for 15 h. After irradiation and radiochemical separation of the electroplated rhodium target, at the optimum condition, 103 Pd was absorbed into Amberlite®IR-93 resin. The preparation of the brachytherapy seed, which is loaded by the resin beads, has also been presented. At least, the method to determine the dosimetric parameters for the seed by experimental measurement has been presented.

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Investigation of palladium-103 production and IR07-103Pd brachytherapy seed preparation

Cited by 9 publications

References 29 publications

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Modelling, Simulation and Dosimetry of ¹⁰³-Pd Eye Plaque Brachytherapy

Production of the ¹⁰³Pd via Cyclotron and Preparation of the Brachytherapy Seed

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Investigation of palladium-103 production and IR07-103Pd brachytherapy seed preparation

Cited by 9 publications

References 29 publications

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

Modelling, Simulation and Dosimetry of 103-Pd Eye Plaque Brachytherapy

Production of the 103Pd via Cyclotron and Preparation of the Brachytherapy Seed

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A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Modelling, Simulation and Dosimetry of ¹⁰³-Pd Eye Plaque Brachytherapy

Production of the ¹⁰³Pd via Cyclotron and Preparation of the Brachytherapy Seed