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In order to study the effects of pentobarbital sodium (Nembutal) anesthesia on the cardiovascular system, mean arterial pressure, cardiac output, stroke volume, total peripheral resistance, plasma and blood volumes, and the circulation time were measured in 20 board-trained unanesthetized dogs and in 20 animals 30 min subsequent to anesthetization with 30 mg/kg Nembutal. The mean arterial pressure, heart rate, cardiac output, and peripheral resistance were all markedly increased ( P < .001) in the anesthetized dogs, while the average blood volume in this group was significantly decreased, presumably due to a decrement in the circulating red cell mass. As might be expected from these results, the circulation time was decreased ( P < .001) in the anesthetized group. These data indicate that pentobarbital sodium exerts a profound influence on the cardiovascular system and serve as a reminder that the ubiquity of Nembutal anesthesia in experimental medicine mandates that the investigator appreciate the altered cardiovascular system with which he is working.

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In dogs cooled to 25 C. and in animals maintained at this rectal temperature for 2 and 4 hours there was a progressive increase in K and decrease in Na content of the left ventricular muscle, with no change in total Cl and H 2 O. Animals heated to a rectal temperature of 41.5 C. for 1 hour exhibited an elevated total K and no change in total Na, Cl and H 2 O contents of the myocardium.

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Combination of CO stretch and NH, bend7; v(C0) NH, bending,? 6NH deformation Combination of CO stretch and NH, bend7 ; 6NH Probably due to different combination of CO stretch v(C-N) 6~ A,NH, rocking6 A, and B,NH, rocking B,NH, rocking6 B,NH, wagging 7 v(C-N) 6* Out of plane skeletal mode; NH, wagging + CO out of plane B,NH, wagging; NH, wagging + CO out of plane deformation { and NH bend taken in pairs * These frequencies relate to complexes of urea with cetane, cetyl bromide, lauryl alcohol (which give essentially similar spectra), and to urea complexes of hexanoic acid, pelargonic acid, and diethyl adipate, but not to that of adipic acid. t Values quoted are for urea only.

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