Cortisone Fore-Treatment of Adrenalectomized Rats Infused With Globin and Dextran

Acute Circulatory Collapse of the Adrenalectomized Dog Following Plasma Infusion

“…0 ' 10 In neither case is prior sensitization of the animal to the lethal agent required, yet the pattern of response is anaphylactoid in character. Dextran, in the rat, liberates histaruine.…”

“…Dextran, in the rat, liberates histaruine. 11 Death can be prevented by prior administration of the antihistaminic drug Phenergan, 9 by cortisone, 10 ' 12 and to a lesser extent by epinephrine. 13 Any of these therapies prevent the development of cyanosis and prostration, but do not prevent a generalized edema.…”

Screening of Possible Therapeutic Agents by Means of Experimental Replicas of Connective‐tissue Diseases

“…Subsequent investigations have shown that, in crude egg white, the ovomucoid fraction carries the activity and that, essentially, responses can be obtained also with a variety of other substances such as dextran, globin, hyaluronidase, polyvinylpyrrolidone, and 48/80. [23][24][25][26] It is not yet fully understood what chemical and physical characteristics a substance must possess to be effective in this respect. Because of the highmolecular polysaccharidic nature of many of these compounds, it is suggested that they would manifest their phlogogenic activity by influencing the degree of polymerisation of the ground substance, thus increasing the vascular permeability in certain elective regions.…”

The Pituitary and Adrenals

“…Pretreatment with cortisone prevented these reactions (80). Adrenalectomized rats subjected to anaphylactoid shock revealed that death was attributable to progressive slowing of the peripheral circulation, pooling and sequestration of blood in the capillaries, stasis, and eventual circulatory collapse.…”