Among the drugs considered illicit in the West, the Cannabis sativa plant is the most consumed: around 4% of the adult population, 10% of these users are in a situation of dependence. However, the medicinal use of this herb dates back to the early days of the emergence of our own species: some anthropologists theorize that some of the genus Homo has progressed in the struggle for survival with other hominids precisely because of the advanced knowledge – kept to the proper proportions – it possessed of plants like Cannabis. Millennia later, science – even focusing intensely on the chemical characterization of its more than 530 bioactive components – was still not able to generate verifiable hypotheses in order to explain two of the most remarkable characteristics of the recreational use of this plant: because small chemical changes potentiated the effect of the drug up to 100 times and, mainly, because it would be virtually impossible for an individual to suffer a lethal overdose of the substance. To overcome this paradigm, some compounds derived from delta-ninetetrahydrocannabinol (Δ9-THC) - the main component of cannabis – were radioactively marked in an experimental study and, after their induction, it was discovered that they had tropism by brain membranes and that their binding was saturated and stereosleptic. Such evidence strongly suggested the existence of endogenous receptors for the drug and it was these findings that led to the discovery of the Endocanabinoid System (SEC): a physiological apparatus made up of endogenous receptors and binders, philogenetically conserved, responsible for several controls related to neuronal homeostasis.
Resumo Este estudo reflete sobre o plágio e a fraude na produção científica brasileira por meio de revisão integrativa de artigos publicados entre janeiro de 2009 e junho de 2019. As publicações foram buscadas nas bases DOAJ, Lilacs, PubMed, SciELO e Web of Science, com os descritores exatos “plagiarism”, “scientific misconduct”, “fraud” e “Brazil”. Com a rápida expansão da internet e o desenvolvimento tecnológico, os casos de má conduta na produção científica aumentaram, ocorrendo, por exemplo, adulteração, invenção ou reutilização de dados, múltiplas submissões, conflitos de autoria e de interesses, publicação “salame” (fracionada) e plágio. Entre as más condutas acadêmicas mais comuns estão a “cola” e o plágio, presentes nos mais diversos níveis de ensino, da educação básica à educação superior.
The historical interest in the use of physical evaluation skills in clinical settings gained new notoriety at the end of the 20th century with evidence that patients in intensive care units experienced increased morbidity and mortality related to poor nutritional status before and/or during their admission. This awareness of the adverse effects of malnutrition led to the need for screening and evaluation tools to identify nutritional risk. no clinical finding of EFN should be considered a diagnosis per se. It is academic, scientific and clinical consensus that its results should be interpreted as suggestive, being crucial to consider the other methods of clinical evaluation of the patient's nutritional status for the correct global nutritional diagnosis. However, the systematic and periodic repetition of the test may help to follow the evolution of the individual's nutritional status, especially in the long term. In summary, although it requires specialized training and continuous practice of the evaluator and/or the team – in addition to requiring complementary nutritional information – the physical nutritional examination can still be considered an effective adjuvant method in the clinical evaluation of the patient’s nutritional status.
Phenylketonuria is an inborn error of metabolism of autosomal recessive inheritance, with partial or total deficiency of the phenylalanine hydroxylase hepatic enzyme, which converts L-phenylalanine into tyrosine, thus causing accumulation of phenylalanine at the brain and serum level, interfering in the brain protein synthesis and entailing serious deficits. The objective of this study was to analyze the effectiveness of Phenylketonuria Diagnosis in the neonatal treatment reference service. This is a cross-sectional, analytical study with a quantitative approach, documented with retrospective data collection. Sociodemographic data, diagnosis, onset of treatment and the coverage rate analysis were grouped on a quadrennial basis. The sample consisted of 14 patients, from whom 57.1% had records of birth and collection time. In variable days of life, 28.6% were screened within the recommended period, 71.4% were diagnosed up to one month of life and 1 case at 3 years of age, for the onset of treatment (14.3%). The ideal collection would be performed up to 30 days of life. The lowest coverage rate for quadrennial was between 2014-2017 with 84.3%, with an incidence of 1:21,933. In conclusion, we highlight the need to optimize the neonatal screening service in order to make early diagnosis, begin specific treatment and minimize or eradicate irreversible sequelae.
The deaf teacher is a professional who differs from another in the way he communicates, and the language used by these professionals is the Brazilian Sign Language (LIBRAS). The objective: to verify the inclusion of deaf teachers in higher education as well as to verify the assistive technologies that contribute to this process and the reality of these professionals. The methodology was a literature review of articles published between 2009 and 2017. Data werecollected from the following databases: Latin American and Caribbean Health Sciences Literature (LILACS), Scientific Electronic Library Online (SCIELO) and National Library of Medicine (PUBMED), using the keywords: teachers, deafness, universities, inclusion, assistive technologies and disability. The results showed that the inclusion of deaf teachers in higher education occurs due to the laws that determine the appointment of deaf teaching professionals as priorities for teaching LIBRAS courses in universities, being LIBRAS an Assistive Technology (TA) for the inclusion of these professionals. However, deaf teachers showed isolation due to the difficulty of communication with other teachers, having difficulties to exchange experiences beyond the strangeness of the students, about the didactics, methodology and evaluation of the deaf teacher.
To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea. Methods: Eighteen male albino Wistar rats were divided into three groups. N G-nitro-L-arginine methyl ester (L-NAME) was intraperitoneally administered to induce oxidative stress. TBARS and plasma nitric oxide levels were analyzed in all groups. Histopathology of the liver and vascular tissue was performed. Results: Statistically significant differences were seen in liver, brain and spinal cord TBARS levels. Conclusions: Following the use of L-NAME, hepatic tissue increased the number of Kupffer cells as oxidative stress and inflammatory response increased. The use of L-NAME caused an increase in lipid peroxidation products and, consequently, in oxidative stress in animals. Hydroxyurea doses of 35 mg / kg / day reduced TBARS values in liver, brain and spinal cord.
The subject discussed refers to the importance of physical activity for people with disabilities, both in physical and psychological aspects. The general objective of this work is to identify the relationship of the person with disability to the sport, as guaranteed by the Federal Constitution, giving the person with disability the right to the sport. As a specific objective, to analyze through journalistic texts what is the perception of the person with disability in face of his/her limitations. The methodology used will be an analytical approach, together with bibliographic and documentary research. The relevance for the study of this theme is the look at the person with disability, which is often forgotten by the public power, or pre-judged by the society that most of the times does not know the concept of disability, or when they come across it, they do not know how to act or how to treat a person with disability. Maybe because they don't even know how they think according to their current life condition, as to the difficulties, as to the accessibility, as to the expectations, as to the way they are seen or treated by society. This raises a question: How are people with disabilities treated by society and public authorities? Are their rights being respected? This answer can be traced back to a critical analysis of a person with disability's discourse.
This article is about the Statute of the Indian from the educational point of view of equality. It aims to approach one of the branches of social rights, regarding education. This education is protected by the 1988 Constitution of the Federative Republic of Brazil and must be provided on an equal basis for students of basic education and indigenous academics. It is a fact that traditional populations, from basic education, receive an education in a different way, because of their language, customs. Based on this premise, the research sought to answer why offer differentiated treatment in basic education (primary and secondary) and not give the necessary support in higher education? In this context, we sought to get to know the reality of the indigenous peoples in terms of education, from the first steps until they entered the University. In addition, factors were pointed out that make it difficult for these scholars to remain in universities and the possible ways to attenuate the existing discrepancies in education and opportunity between indigenous and non-indigenous people. The methodology applied was the bibliographic review, with the use of books, legislation (especially the Statute of the Indian) and articles hosted in online journals. The results showed that despite the advances, there is still a long way to go to achieve an ideal education.
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