Background Hand, foot, and mouth disease (HFMD) is a viral infection caused by a virus from the enterovirus genus of picornavirus family that majorly affects children. Though most cases of HFMD do not cause major problems, the outbreaks of Enterovirus 71 (EV71) can produce a high risk of neurological sequelae, including meningoencephalitis, lung difficulties, and mortality. In Asia, HFMD caused by EV71 has emerged as an acutely infectious disease of highly pathogenic potential, which demands the attention of the international medical community. Main body of the abstract Some online databases including NCBI, PubMed, Google Scholar, ProQuest, Scopus, and EBSCO were also accessed using keywords relating to the topic for data mining. The paid articles were accessed through the Centre Library facility of Siksha O Anusandhan University. This work describes the structure, outbreak, molecular epidemiology of Enterovirus 71 along with different EV71 vaccines. Many vaccines have been developed such as inactivated whole-virus live attenuated, subviral particles, and DNA vaccines to cure the patients. In Asia–Pacific nations, inactivated EV71 vaccination still confronts considerable obstacles in terms of vaccine standardization, registration, price, and harmonization of pathogen surveillance and measurements. Short conclusion HFMD has emerged as a severe health hazard in Asia–Pacific countries in recent decades. In Mainland China and other countries with high HFMD prevalence, the inactivated EV71 vaccination will be a vital tool in safeguarding children's health. When creating inactivated EV71 vaccines, Mainland China ensured maintaining high standards of vaccine quality. The Phase III clinical studies were used to confirm the safety and effectiveness of vaccinations. Graphical Abstract

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The genus Ocimum has many species belonging to the Lamiaceae family that are used to treat various diseases and disorders. Ocimum basilicum has been found to contain over 200 chemical components in different plant parts. The bioactive components showed the presence of α-linalool, camphor, limonene, thymol, citral, β-linalool, estragole, etc. O. basilicum exhibits anti-inflammatory, antioxidant, antiulcer, antiviral, hypoglycemic, hypolipidemic, antimicrobial, anticancer, wound-healing activities, etc. They have also been used to treat fevers, digestive issues, stomach cramps, nausea, gastritis, migraine, diarrhea. This review aims to provide information about the chemical compounds and biological activities of O. basilicum var thyrsiflora (Thai basil). To the best of our knowledge, this is the first review outlining the innovative ethnomedicinal approach to oral health care that, through its strong phytoconstituents, has the potential to improve modern medicine.

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Propolis is a promising natural product that has been extensively researched and studied for its potential health and medical benefits. The lack of requisite high oil-containing propolis and existing variation in the quality and quantity of essential oil within agro-climatic regions pose a problem in the commercialization of essential oil. As a result, the current study was carried out to optimize and estimate the essential oil yield of propolis. The essential oil data of 62 propolis samples from ten agro-climatic areas of Odisha, as well as an investigation of their soil and environmental parameters, were used to construct an artificial neural network (ANN) based prediction model. The influential predictors were determined using Garson’s algorithm. To understand how the variables interact and to determine the optimum value of each variable for the greatest response, the response surface curves were plotted. The results revealed that the most suited model was multilayer-feed-forward neural networks with an R2 value of 0.93. According to the model, altitude was found to have a very strong influence on response, followed by phosphorous & maximum average temperature. This research shows that using an ANN-based prediction model with a response surface methodology technique to estimate oil yield at a new site and maximize propolis oil yield at a specific site by adjusting variable parameters is a viable commercial option. To our knowledge, this is the first report on the development of a model to optimize and estimate the essential oil yield of propolis.

Ocimum basilicum var. thyrsiflora is valuable for its medicinal properties. The barriers to the commercialization of essential oil are the lack of requisite high oil-containing genotypes and variations in the quantity and quality of essential oils in different geographic areas. Thai basil’s essential oil content is significantly influenced by soil and environmental factors. To optimize and predict the essential oil yield of Thai basil in various agroclimatic regions, the current study was conducted. The 93 datasets used to construct the model were collected from samples taken across 10 different agroclimatic regions of Odisha. Climate variables, soil parameters, and oil content were used to train the Artificial Neural Network (ANN) model. The outcome showed that a multilayer feed-forward neural network with an R squared value of 0.95 was the most suitable model. To understand how the variables interact and to determine the optimum value of each variable for the greatest response, the response surface curves were plotted. Garson’s algorithm was used to discover the influential predictors. Soil potassium content was found to have a very strong influence on responses, followed by maximum relative humidity and average rainfall, respectively. The study reveals that by adjusting the changeable parameters for high commercial significance, the ANN-based prediction model with the response surface methodology technique is a new and promising way to estimate the oil yield at a new site and maximize the essential oil yield at a particular region. To our knowledge, this is the first report on an ANN-based prediction model for Ocimum basilicum var. thyrsiflora.