Periodontitis is a chronic inflammatory disease of the gums. The incidence of periodontitis is increasing all over the world. In patients with periodontitis, there is gradual destruction of the periodontal ligament and the alveolar bone, and later, in advanced stages, there is tooth loss. Different microorganisms, the host’s immune response, and various environmental factors interact in the progression of this chronic inflammatory disease. In the present review, we discuss the epidemiology, clinical features, diagnosis, and complications of periodontitis. We also discuss the association of chronic inflammation found in periodontitis with various other systemic diseases, which include cardiovascular, respiratory, diabetes, Alzheimer’s, cancer, adverse pregnancy, and multiple myeloma, and also highlight microbial carcinogenesis and the microRNAs involved. The latest updates on the molecular mechanism, possible biomarkers, and treatment procedures may be beneficial for diagnostic and therapeutic purposes.

Background Hand, foot, and mouth disease (HFMD) is a viral infection caused by a virus from the enterovirus genus of picornavirus family that majorly affects children. Though most cases of HFMD do not cause major problems, the outbreaks of Enterovirus 71 (EV71) can produce a high risk of neurological sequelae, including meningoencephalitis, lung difficulties, and mortality. In Asia, HFMD caused by EV71 has emerged as an acutely infectious disease of highly pathogenic potential, which demands the attention of the international medical community. Main body of the abstract Some online databases including NCBI, PubMed, Google Scholar, ProQuest, Scopus, and EBSCO were also accessed using keywords relating to the topic for data mining. The paid articles were accessed through the Centre Library facility of Siksha O Anusandhan University. This work describes the structure, outbreak, molecular epidemiology of Enterovirus 71 along with different EV71 vaccines. Many vaccines have been developed such as inactivated whole-virus live attenuated, subviral particles, and DNA vaccines to cure the patients. In Asia–Pacific nations, inactivated EV71 vaccination still confronts considerable obstacles in terms of vaccine standardization, registration, price, and harmonization of pathogen surveillance and measurements. Short conclusion HFMD has emerged as a severe health hazard in Asia–Pacific countries in recent decades. In Mainland China and other countries with high HFMD prevalence, the inactivated EV71 vaccination will be a vital tool in safeguarding children's health. When creating inactivated EV71 vaccines, Mainland China ensured maintaining high standards of vaccine quality. The Phase III clinical studies were used to confirm the safety and effectiveness of vaccinations. Graphical Abstract

Background:The temporomandibular joint is a hinge joint which is formed by the mandible with articulation of the jaw with the cranium. The morphology of the mandible is evaluated by measuring the gonial angle ramus height and bigonial width.Aim:The aim of this study to investigate the impact of age and gender on ramus height, gonial angle and bigonial width in the dentulous odisha population using digital panaromic radiographs.Materials and Methods:A total of 50 dentulous participants (25 males and 25 females) aged between 10 and 80 years were included in this study. The data were collected after comprehensive examination by 1 principal and two coinvestigators.Statistical Analysis:The mean difference between gender and different age groups was calculated using SPSS version 20.0. Unpaired t-test and one-way ANOVA were used for comparison studied parameters according to gender, side and different age groups followed by Tukey's post hoc test.Results:A statistically significant gender difference was seen for gonial angle, ramus height and bigonial width. All the parameters increased with increase in age. This difference was statistically significant on the right side for gonial angle and ramus height.Conclusion:This study is useful as for age and sex determination using mandible as primary object in forensic odontology.

Background: In both waves of COVID-19 infections, loss of taste was noted in a disproportionately high number of individuals. However, there is a considerable risk of dental disease during and after COVID -19 infections. Aim: Our aim here is to study the oral manifestation of the COVID -19 infections and make a comparison of the severity of presentation in the second wave with the first wave among the general population in Bhubaneswar, city of Odisha, India. Methods: A detailed online questionnaire was developed focusing on the oral manifestation during both the waves using Google forms. Results: Out of a total of 380 RT PCR positive cases, 91/169 and 167/211 cases with oral manifestation were obtained in the first and second waves, respectively. We found 41 (24.26 %) in the first wave and 63 (29.85 %) in the second wave of patients with oral manifestations over the age of 50. Patients receiving oxygen or using a ventilator were found to be 15 (8.9 %) in the first wave and 59 (28%) in the second wave. Conclusion: This is the first study to evaluate the correlation of oral infection with COVID 19 in different waves. This difference could be correlated with the virulence of viruses with mutated strains.

The present era accentuate the use of alternative medicines as drugs extracted from several plant parts. These herbal medicines otherwise called ethnomedicines are now the source of many imperative drugs in this contemporary world. Furthermore with ever rising oral problems by luxurious lifestyle in this modern society, there is a soaring need for use of potent medicinal plants like horse radish (Moringa oleifera Lam.) against various oral ailments. Therefore, use of herbal medicines in reducing the adverse effects of various conventional allopathic medicines and harmful side effects of conventional antibiotics has emerged as an evolved technique in pharmaceutical science. The present review emphasizes the antipathogenic potentiality of M. oleifera along with their known therapeutic properties through biologically active compounds (phytoconstituents) and ethnomedicinal uses. Various ethno‐pharmacological studies of the plant parts with their nutritional value and multifarious medicinal uses including oral health care are being quoted in present review. This review will foster future research on phytoconstituent analysis, bioefficacy assessment for oral micro flora and ethno‐pharmaceutical importance of M. oleifera in the field of medical science with special reference to dentistry. Consequently, this innovative ethnomedicinal approach for oral health care may supplement the modern medicine through its potent phytoconstituents.