Background Hand, foot, and mouth disease (HFMD) is a viral infection caused by a virus from the enterovirus genus of picornavirus family that majorly affects children. Though most cases of HFMD do not cause major problems, the outbreaks of Enterovirus 71 (EV71) can produce a high risk of neurological sequelae, including meningoencephalitis, lung difficulties, and mortality. In Asia, HFMD caused by EV71 has emerged as an acutely infectious disease of highly pathogenic potential, which demands the attention of the international medical community. Main body of the abstract Some online databases including NCBI, PubMed, Google Scholar, ProQuest, Scopus, and EBSCO were also accessed using keywords relating to the topic for data mining. The paid articles were accessed through the Centre Library facility of Siksha O Anusandhan University. This work describes the structure, outbreak, molecular epidemiology of Enterovirus 71 along with different EV71 vaccines. Many vaccines have been developed such as inactivated whole-virus live attenuated, subviral particles, and DNA vaccines to cure the patients. In Asia–Pacific nations, inactivated EV71 vaccination still confronts considerable obstacles in terms of vaccine standardization, registration, price, and harmonization of pathogen surveillance and measurements. Short conclusion HFMD has emerged as a severe health hazard in Asia–Pacific countries in recent decades. In Mainland China and other countries with high HFMD prevalence, the inactivated EV71 vaccination will be a vital tool in safeguarding children's health. When creating inactivated EV71 vaccines, Mainland China ensured maintaining high standards of vaccine quality. The Phase III clinical studies were used to confirm the safety and effectiveness of vaccinations. Graphical Abstract

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The genus Ocimum has many species belonging to the Lamiaceae family that are used to treat various diseases and disorders. Ocimum basilicum has been found to contain over 200 chemical components in different plant parts. The bioactive components showed the presence of α-linalool, camphor, limonene, thymol, citral, β-linalool, estragole, etc. O. basilicum exhibits anti-inflammatory, antioxidant, antiulcer, antiviral, hypoglycemic, hypolipidemic, antimicrobial, anticancer, wound-healing activities, etc. They have also been used to treat fevers, digestive issues, stomach cramps, nausea, gastritis, migraine, diarrhea. This review aims to provide information about the chemical compounds and biological activities of O. basilicum var thyrsiflora (Thai basil). To the best of our knowledge, this is the first review outlining the innovative ethnomedicinal approach to oral health care that, through its strong phytoconstituents, has the potential to improve modern medicine.

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