Cellular angiofibroma is a rare distinctive mesenchymal neoplasm of the vulva or perineal region. We report here one unique extravulvar case. A 43-year-old woman presented with an asymptomatic tumor, 7 cm in diameter, located in the subcutaneous tissue of the chest below the left submammary sulcus. Histologically, the lesion was composed of uniform spindled stroma cells, numerous thick-walled vessels, and scarce mature adipocytes. An additional feature was the presence of prominent perivascular lymphoid aggregates. The stromal cells were positive for vimentin and negative for CD34 and muscle, epithelial, myoepithelial, or neural markers. Although nasopharyngeal angiofibroma or the group of acral angiofibromas have a concurrent heading, cellular angiofibroma should not be mistaken with them. Differential diagnosis of this distinctive tumor especially includes aggressive angiomyxoma, angiomyofibroblastoma, superficial angiomyxoma, vascular myxolipoma, and other tumors with spindle cells reminiscent of those in angiofibroma.
In the present report, we describe a cutaneous myofibroma with a monophasic pattern. The patient was a 12-year-old white boy with an asymptomatic yellow nodule on his glans penis for about 2 1/2 months. The nodular pattern of growth is distinctive: nests of plump spindle cells with a tendency toward interstitial hyalinization within the dermis. Confirmation of the myofibroblastic nature of the proliferation was obtained by histochemical and immunohistochemical studies. The tumor cells showed immunoreactivities for vimentin, alpha-smooth-muscle actin, and collagen type IV but did not stain for desmin. To the best of our knowledge, this is the first case of cutaneous myofibroma to occur on the glans penis. This tumor should be included in the differential diagnosis of mesenchymal neoplasms of the penis.
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