Extravulvar subcutaneous cellular angiofibroma

Abstract

Cellular angiofibroma is a rare distinctive mesenchymal neoplasm of the vulva or perineal region. We report here one unique extravulvar case. A 43-year-old woman presented with an asymptomatic tumor, 7 cm in diameter, located in the subcutaneous tissue of the chest below the left submammary sulcus. Histologically, the lesion was composed of uniform spindled stroma cells, numerous thick-walled vessels, and scarce mature adipocytes. An additional feature was the presence of prominent perivascular lymphoid aggregates. The stromal cells were positive for vimentin and negative for CD34 and muscle, epithelial, myoepithelial, or neural markers. Although nasopharyngeal angiofibroma or the group of acral angiofibromas have a concurrent heading, cellular angiofibroma should not be mistaken with them. Differential diagnosis of this distinctive tumor especially includes aggressive angiomyxoma, angiomyofibroblastoma, superficial angiomyxoma, vascular myxolipoma, and other tumors with spindle cells reminiscent of those in angiofibroma.

Desmin expression in spindle cell lipomas: a potential diagnostic pitfall

“…This is a neoplasm that consists of spindle cells in a fibromyxoid stroma and features a minor adipocytic component and numerous blood vessels, often with fibrotic walls. In contrast to spindle cell lipoma, cellular angiofibroma occurs in both men and women and appears to be restricted to the groin and pelvic areas (although one case has been reported in the subcutaneous tissue of the chest [6]). Furthermore, the expression of CD34 is not consistent in this tumor.…”

Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region

“…Cellular angiofi broma was fi rst described by Nucci et al 6 in 1997 as a distinctive benign soft tissue tumor of the vulva, distinguishable from AMF; their report was followed by a few case reports. [7][8][9][10][11] Later, AMF-like tumor and cellular angiofi broma were considered to be similar entities, and Iwasa and Fletcher 3 reported 51 cases of cellular angiofi broma, occurring in both sexes, including the entity AMF-like tumor.…”

Coxalgia? Call the Gynecologist

“…AA is a poorly circumscribed lesion with an infiltrative edge, more myxoid stroma, and fewer cells than CA and has a high recurrence risk [1,2]. AMF is a well-circumscribed lesion characterized by alternating hypocellular and hypercellular areas with cells arranged around the blood vessels [1].…”

“…CA is a benign, slow-growing, and painless mesenchymal tumor that occurs in middle-aged/postmenopausal women [1] in the subcutaneous or intradermal vulvovaginal region [1] or rarely in extravulvar subcutaneous sites [2][3][4][5][6] (Table 1). To the best of our knowledge, this is the fourth case of extravulvar CA diagnosed in a woman and the first case diagnosed in the retroperitoneum of a woman subsequently treated by laparoscopy.…”