Solitary Cutaneous Myofibroma of the Glans Penis

Val-Bernal, J. Fernando; Mf, Garijo Ayensa

doi:10.1097/00000372-199606000-00014

Cited by 22 publications

(3 citation statements)

References 19 publications

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“…A derivation from myointimal cells has been postulated. A review of the literature suggests that examples of myointimoma have previously been published as leiomyoma, 28 intravascular leiomyoma, 5,15 solitary cutaneous myofibroma, 31 and localized fibrosis of the corpus cavernosum. 21 The strong predilection for the glans, characteristic growth pattern, minimal cytologic atypia, and scarcity of desmin immunoreactivity militate against a diagnosis of leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the Penis

Fetsch

Davis²,

Miettinen³

et al. 2004

The American Journal of Surgical Pathology

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Primary leiomyosarcomas of the penis are very rare. To date, less than 30 have been documented in the English language literature. In this report, we describe the clinical, histopathologic, and immunohistochemical findings in 14 cases retrieved from our files. The patients ranged in age from 43 to 62 years (mean age, 51 years) at the time of initial surgical resection. The tumors involved the prepuce (n = 1), prepuce and distal shaft (n = 1), circumcision scar line (n = 2), circumcision scar line and distal shaft (n = 1), shaft (n = 5), base of the penis (n = 3), and penis, not otherwise specified (n = 1). The lesions ranged in size from 0.5 to 6.0 cm (median size, 1.5 cm) in greatest dimension. Nine tumors were superficially located, two were of indeterminate depth, and three were deep-seated. The superficial tumors were relatively asymptomatic, and seven were reportedly present for 1 year to more than 20 years (median duration, 5 years) before medical attention was sought. In contrast, one deep-seated lesion caused dysuria and difficulty voiding, prompting the patient to seek a clinical opinion within only a few months of the apparent onset. Histologically, all tumors contained smooth muscle cells with both cytologic atypia and mitotic activity. Immunohistochemical studies were available for nine tumors, and immunoreactivity for desmin was present in all instances. All patients were initially treated with a local procedure. Follow-up information is available for 9 of the 14 patients (64%), with a median follow-up interval of 12 years 11 months. Three patients had multiple (two to four) local recurrences. Two of these patients were ultimately treated with a wide local excision or partial penectomy, and both were alive and well at last follow-up. In contrast, one patient, who had four local recurrences and refused a penectomy, developed a distant metastasis 10 months after the fourth recurrence. The best predictors of outcome are tumor depth and tumor size. Superficial leiomyosarcomas of the penis are optimally managed by wide local excision whenever this is technically feasible. Tumors with a deep-seated component may require more aggressive intervention to ensure complete removal.

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Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the Penis

Fetsch

Davis²,

Miettinen³

et al. 2004

The American Journal of Surgical Pathology

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“…Subsequent reports documented that solitary lesions identical to those of infantile myofibromatosis occur in adults more commonly than in children and most of the lesions are located in the dermis. [42][43][44][45][46][47][48][49][50][51][52][53][54][55] Thus, terms such as cutaneous myofibroma and solitary myofibroma in adults have been proposed as the most appropriate designation to describe this distinctive lesion. [43][44][45] Infantile myofibromatosis presents usually before the age of 2 years.…”

Section: Cutaneous Myofibroma and Myopericytomamentioning

confidence: 99%

Perivascular Cell Neoplasms

Sangüeza¹,

Requena²,

Walsh³

2008

Pathology Case Reviews

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Originally, the family of perivascular neoplasms included hemangiopericytomas and glomus tumors. However, tumors once thought to be hemangiopericytomas now have mostly been reclassified into more specific entities. Currently, we recognize a category of mesenchymal tumors that have perivascular localization and myogenic differentiation, which includes PEComas, myofibromas and myopericytomas, and glomus tumors (including malignant cases). Such tumors have broadened the spectrum of vascular neoplasms.

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“…To our best knowledge, there are fewer than 20 cases of penile myointimoma reported in the English literature under this name 2–5 . Previously reported lesions that now might in fact be classified as penile myointimoma include leiomyoma of the glans penis, 6,7 solitary cutaneous myofibroma of the penis 8 and several neoplastic and reactive intravascular proliferations (leiomyomas, leiomyomatosis and fasciitis). A unique feature shared by all observed cases is their predilection to the glans penis.…”

mentioning

confidence: 99%

Penile myointimoma

Turner,

Reith,

Al‐Quran

2009

J Cutan Pathol

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Solitary Cutaneous Myofibroma of the Glans Penis

Cited by 22 publications

References 19 publications

Leiomyosarcoma of the Penis

Leiomyosarcoma of the Penis

Perivascular Cell Neoplasms

Penile myointimoma

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