Objective: The purpose of this study was to evaluate the utility of core needle biopsy as a diagnostic tool for palpable breast lumps in developing countries as compared to fine needle aspiration cytology .Material and Method: all patients attending the surgery outpatient department with palpable breast lumps were subjected to fine needle aspiration cytology and core needle biopsy by the same operator in a single session. Fine needle aspiration cytology was performed by the standard technique. Core needle biopsy was done freehand using a 14G manual core biopsy needle. reporting categories of the two techniques were taken from the standard National Health Service Breast Screening Programme criteria and were compared with the final histopathology results.Results: a total of 107 patients underwent fine needle aspiration cytology and core needle biopsy simultaneously. Histopathology was available for 85 cases. Statistical analysis of fine needle aspiration cytology and core needle biopsy showed no significant difference between the diagnoses offered by core needle biopsy and histopathology while there was a significant difference between fine needle aspiration cytology and histopathology diagnoses. Conclusion:Core needle biopsy detected more breast carcinomas as compared to fine needle aspiration cytology with a sensitivity 95.83% as opposed to 64.58%. Though both the techniques were equally specific (100%), Core needle biopsy was able to correctly categorize borderline / inadequate lesions into definitely benign and malignant categories. We suggest that core needle biopsy should be preferred over fine needle aspiration cytology for the diagnosis of palpable breast lumps with fine needle aspiration cytology being reserved for definitely benign lesions.

Liesegang rings are rarely encountered in routine histopathology practice and are generally described in benign conditions. 1 However, our description in an ovarian neoplasm expands their spectrum in malignancies. [2][3][4] Recently, round to ovoid acellular eosinophilic rings were noted in histological sections from an endometrioid ovarian neoplasm ( Figure 1A-C) of a 36-year-old woman. Interestingly, these were confined to the central necrotic regions, within large endometrioid glands, exhibiting squamous metaplasia. The rings having characteristic concentric laminations around a central amorphous nidus were identified as Liesegang rings. They were nonbirefringent on polarizing microscopy and negative for epithelial membrane antigen (EMA). Their structural details were accentuated with periodic acid-Schiff stain.The smooth walled ovarian mass measured 10 × 7 cm. The cut surface was solid-cystic and revealed blood clots. While sections from the thin cyst wall had tubal type lining, the solid region displayed lobules of proliferating endometrioid glands. Examination of multiple sections revealed only occasional foci of confluent expansile tumor growth measuring >5 mm in greatest dimension. Herein, despite relatively bland nuclear features of lining epithelium and ≤2 mitosis/high-power field, there was architectural 697821I JSXXX10.1177/1066896917697821International Journal of Surgical PathologyJain et al research-article2017 Figure 1. (A) Microscopy revealed an occasional large () expansile lobule measuring >5 mm in greatest dimension, among smaller (→) lobules (hematoxylin and eosin, 20×). (B) Higher magnification of this large lobule revealed confluent endometrioid glands, lined by mildly pleomorphic cells with only occasional mitotic figures (). There were intervening sheets of squamous metaplastic cells and Liesegang rings (→) were seen confined to dilated glands (hematoxylin and eosin, 200×). (C) These rings (→)were seen in regions of necrosis, rimmed by squamous epithelium (hematoxylin and eosin, 400×). (C inset) The characteristic concentric laminations of Liesegang rings (→) were accentuated on PAS histochemistry (periodic acid-Schiff, 400×), but (D) they stained negative for EMA (immunostain, 400×).

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We report a case of chronic myeloid leukemia (CML) that developed after postoperative chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) for breast cancer. A 55-year-old woman was diagnosed with invasive ductal carcinoma which was treated with a modified radical mastectomy followed by six cycles of CAF chemotherapy. Nine years later, she developed CML and locoregional recurrence. Her breast recurrence showed strong estrogen receptor, weak progesterone receptor and strong human epidermal growth factor 2 (score 3+) expression. Her secondary CML in the chronic phase showed a complex variant translocation (CVT) involving chromosomes 9, 22, and 17. Considering that the HER2/neu gene is also located on chromosome 17, this secondary CML in chronic phase with CVT is indeed a rare occurrence. We discuss the associated genetic factors and the possible role of breast cancer chemo/radiotherapy in the development of such CML as well as its treatment and prognosis compared with de novo CML.

This retrospective study aimed to investigate the impact of peritumoral retraction clefts (RC) and tumor-associated tissue eosinophilia (TATE) as predictors of overall survival (OS) in oral squamous cell carcinoma (OSCC) patients. Their relationships with tumor-factors were also examined. Eighty-seven OSCC cases (pTNM: I + II/III + IV; 32/55), post-curative surgery, comprised the study cohort. Three observers independently estimated the percent RC semi-quantitatively in the selected tumor sections. Additionally, stromal eosinophils were counted in ten consecutive high-power fields of intratumoral and peritumoral regions to evaluate the corresponding TATE. The percent RC ranged between 0% -90% (Mean ± SD: 16 ± 24%; Median: 5%). The stromal eosinophils were greater in peritumoral as compared to intratumoral region. The events of death and tumor recurrence were reached in 16 (18.4%) and 36 (41%) cases respectively. The 3-years OS was 69% [Median OS: 1880 days; Mean follow up: 471(Range; 36-1880) days]. Increased percent RC exhibited relationship with pathologic stage (pTNM III&IV), primary tumor (pT III&IV), tumor depth > 4 mm and categorical tumor recurrence. Additionally, peritumoral eosinophilic infiltrates increased with increasing tumor depths and muscle invasion. Kaplan-Meier curves revealed significantly reduced OS in OSCC cases exhibiting: increased percent RC (>2.5%), mild -moderate/absent intratumoral TATE (versus intense TATE) or categorical tumor recurrence. In subsequent multivariate tests, all the three variables retained significance. Additionally, intraclass correlation coefficient demonstrated acceptable internal consistency for the observers who estimated percent RC. In conclusion, RC and intratumoral TATE proved to be independent predictors of OS in our OSCC cohort. Additionally, increased percent RC pointed towards aggressive tumor behaviour.