The Impact of Peritumoral Retraction Clefting &amp; Intratumoral Eosinophils on Overall Survival in Oral Squamous Carcinoma Patients

Jain, Dhruv; Tikku, Gargi; Bhadana, Pallavi; Dravid, Chandrashekhar; Grover, Rajesh K.

doi:10.1007/s12253-017-0328-x

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…Previously, we proposed a possible mechanism for the formation of tumor cell clusters in tumor MVs[ 21 ]. This mechanism is associated with the retraction of tumor cells from the underlying stroma and the formation of hollow structures with tumor cells in the lumen, which corresponds to the previously described phenomenon of retraction clefts[ 27 , 28 , 29 ]. Subsequently, the inner surface of the described hollow structures may be partially or completely lined with endothelium.…”

Section: Discussionmentioning

confidence: 78%

“…The presence of retraction clefts: This phenomenon has been described in some tumor types and involves the presence of empty spaces around tumor nests[ 25 , 26 ]. Several studies have demonstrated that the presence of retraction clefts may be associated with a poor prognosis in patients with various malignant tumors[ 27 - 29 ] or more aggressive tumors[ 30 ]. In LUSC, retraction clefts were detected in 77% of the samples (Figure 2G ).…”

Section: Resultsmentioning

confidence: 99%

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Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

Senchukova,

Kalinin,

Volchenko

2024

World J Clin Oncol

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BACKGROUND Lung cancer (LC) is the leading cause of morbidity and mortality among malignant neoplasms. Improving the diagnosis and treatment of LC remains an urgent task of modern oncology. Previously, we established that in gastric, breast and cervical cancer, tumor microvessels (MVs) differ in morphology and have different prognostic significance. The connection between different types of tumor MVs and the progression of LC is not well understood. AIM To evaluate the morphological features and clinical significance of tumor MVs in lung squamous cell carcinoma (LUSC). METHODS A single-center retrospective cohort study examined medical records and archival paraffin blocks of 62 and 180 patients with stage I-IIIA LUSC in the training and main cohorts, respectively. All patients underwent radical surgery (R0) at the Orenburg Regional Cancer Clinic from May/20/2009 to December/14/2021. Tumor sections were routinely processed, and routine Mayer's hematoxylin and eosin staining and immunohistochemical staining for cluster of differentiation 34 (CD34), podoplanin, Snail and hypoxia-inducible factor-1 alpha were performed. The morphological features of different types of tumor MVs, tumor parenchyma and stroma were studied according to clinicopathological characteristics and LUSC prognosis. Statistical analysis was performed using Statistica 10.0 software. Univariate and multivariate logistic regression analyses were performed to identify potential risk factors for LUSC metastasis to regional lymph nodes (RLNs) and disease recurrence. Receiver operating characteristic curves were constructed to discriminate between patients with and without metastases in RLNs and those with and without disease recurrence. The effectiveness of the predictive models was assessed by the area under the curve. Survival was analyzed using the Kaplan-Meier method. The log-rank test was used to compare survival curves between patient subgroups. A value of P < 0.05 was considered to indicate statistical significance. RESULTS Depending on the morphology, we classified tumor vessels into the following types: normal MVs, dilated capillaries (DCs), atypical DCs, DCs with weak expression of CD34, "contact-type" DCs, structures with partial endothelial linings, capillaries in the tumor solid component and lymphatic vessels in lymphoid and polymorphocellular infiltrates. We also evaluated the presence of loose, fine fibrous connective tissue (LFFCT) and retraction clefts in the tumor stroma, tumor spread into the alveolar air spaces (AASs) and fragmentation of the tumor solid component. According to multivariate analysis, the independent predictors of LUSC metastasis in RLNs were central tumor location (P < 0.00001), the presence of retraction clefts (P = 0.003), capillaries in the tumor solid component (P = 0.023) and fragmentation in the tumor solid component (P = 0.009), whereas the independent predictors of LUSC recurrence were tumor grade 3 (G3) (P = 0.001), stage N2 (P = 0.016), the presence of LFFCT in the tumor stroma (P < 0.00001), fragmentation of the tumor solid component (P = 0.0001), and the absence of tumor spread through the AASs (P = 0.0083). CONCLUSION The results obtained confirm the correctness of our previously proposed classification of different types of tumor vessels and may contribute to improving the diagnosis and treatment of LUSC.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

Senchukova,

Kalinin,

Volchenko

2024

World J Clin Oncol

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“…The connection between peritumoral retraction clefting and the risk of disease relapse in patients with various malignancies, including breast cancer[ 36 ] and oral squamous cell carcinoma[ 37 ], has also been described. However, in LC, this phenomenon has practically not been studied.…”

Section: Discussionmentioning

confidence: 99%

Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis

Senchukova,

Kalinin,

Volchenko

2024

World J Exp Med

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BACKGROUND Lung cancer (LC) is a global medical, social and economic problem and is one of the most common cancers and the leading cause of mortality from malignant neoplasms. LC is characterized by an aggressive course, and in the presence of disease recurrence risk factors, patients, even at an early stage, may be indicated for adjuvant therapy to improve survival. However, combined treatment does not always guarantee a favorable prognosis. In this regard, establishing predictors of LC recurrence is highly important both for determining the optimal treatment plan for the patients and for evaluating its effectiveness. AIM To establish predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa lung squamous cell carcinoma (LSCC). METHODS A retrospective case-control cohort study included 69 patients with LSCC who underwent radical surgery at the Orenburg Regional Clinical Oncology Center from 2009 to 2018. Postoperatively, all patients received adjuvant chemotherapy. Histological samples of the resected lung were stained with Mayer's hematoxylin and eosin and examined under a light microscope. Univariate and multivariate analyses were used to identify predictors associated with the risk of disease recurrence. Receiver operating characteristic curves were constructed to discriminate between patients with a high risk of disease recurrence and those with a low risk of disease recurrence. Survival was analyzed using the Kaplan-Meier method. The log-rank test was used to compare survival curves between patient subgroups. Differences were considered to be significant at P < 0.05. RESULTS The following predictors of a high risk of disease recurrence in patients with stage IIb-IIa LSCC were established: a low degree of tumor differentiation [odds ratio (OR) = 7.94, 95%CI = 1.08-135.81, P = 0.049]; metastases in regional lymph nodes (OR = 5.67, 95%CI = 1.09-36.54, P = 0.048); the presence of loose, fine-fiber connective tissue in the tumor stroma (OR = 21.70, 95%CI = 4.27-110.38, P = 0.0002); and fragmentation of the tumor solid component (OR = 2.53, 95%CI = 1.01-12.23, P = 0.049). The area under the curve of the predictive model was 0.846 (95%CI = 0.73-0.96, P < 0.0001). The sensitivity, accuracy and specificity of the method were 91.8%, 86.9% and 75.0%, respectively. In the group of patients with a low risk of LSCC recurrence, the 1-, 2- and 5-year disease-free survival (DFS) rates were 84.2%, 84.2% and 75.8%, respectively, while in the group with a high risk of LSCC recurrence the DFS rates were 71.7%, 40.1% and 8.2%, respectively (P < 0.00001). Accordingly, in the first group of patients, the 1-, 2- and 5-year overall survival (OS) rates were 94.7%, 82.5% and 82.5%, respectively, while in the second group of patients, the OS rates were 89.8%, 80.1% and 10.3%, respectively (P < 0.00001). CONCLUSION The developed method allows us to identify a group of patients at high risk of disease recurrence and to adjust to ongoing treatment.

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“…Furthermore, a previous study illustrated a correlation between an increased overall survival as well as disease-free survival and the intensity of tumor-associated tissue eosinophilia (52). Especially, overall survival would increase in intratumoral tumor-associated tissue eosinophilia when compared with other sites (53). In addition, a prospective cohort study found that patients with EPEs had a significantly better survival than those with non-EPEs (a median survival of 16.8 months compared with 7.7 months) (17).…”

Section: Prognostic Significance Of Mepementioning

confidence: 92%

A narrative review of malignant eosinophilic pleural effusion: incidence, etiology and prognostic significance

Li¹,

Lin²,

Wang³

2021

Ann Palliat Med

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Eosinophilic pleural effusion (EPE) is defined as a pleural fluid with an eosinophilic count exceeding 10% and currently considered to be mainly caused by malignancy. However, the incidence, etiology and prognostic significance of malignant eosinophilic pleural effusion (MEPE) have not been studied extensively yet. Thus, the objective of this review was to summarize medical studies regarding MEPE to 2020 throughout an extensive search of PubMed. Overall, MEPE was a disease associated with multiplecytokines-mediated immunity and varied from 4% to 92% of patients who had EPE. The discrepancy of the MEPE prevalence among studies could be explained by the development of diagnostic technology, disparity of study population, or various disease spectrum over time. Data summarized in this review demonstrated that the incidence of malignancy was lower in EPEs than in non-EPEs (29.7% vs. 32.9%). Additionally, MEPE could be a manifestation of a great variety of tumor subtypes, among which lung cancer was the most common cause and accounted for more than 34% of cases. The second common causes were non-Hodgkin lymphoma and metastatic cancers with unknown primary site which were observed in around 5% of cases, respectively. The presence of eosinophils in the pleural effusion may be associated with a positive prognosis of MEPE. Besides, the prognosis of MEPE may be related to the percentage of eosinophils in the pleural fluid. More extensive studies, however, are warranted to validate these findings.

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The Impact of Peritumoral Retraction Clefting & Intratumoral Eosinophils on Overall Survival in Oral Squamous Carcinoma Patients

Cited by 9 publications

References 24 publications

Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis

A narrative review of malignant eosinophilic pleural effusion: incidence, etiology and prognostic significance

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