Protective effect of 313-hydioxy-2,3-dihydrowithanolide F against CCI4-induced hepatotoxicity has been assessed and the compound was found to possess marked protective effect. A comparison of the protective properties showed that it is more active than hydrocortisone on a weight basis.
Pharmacological investigations with alcoholic extract, total alkaloids and aqueous extract of the fruits of W i t hania c o a g u l a n s showed the presence of central nervous system depressant effect characterised by decreased spontaneous activity and potentiation of pentobarbitone hypnosis. However, the extracts showed no analgesic and anticonvulsant activity. In addition, alcoholic extract and total alkaloids showed a significant antiinflammatory effect in acute inflammation induced with egg albumin, subacute inflammation induced with formalin and granulation tissue formation by cotton pellet method.
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