Protective Effect of 3-ß-Hydroxy-2,3-dihydrowithanolide F against CCl₄-induced Hepatotoxicity

Abstract

Protective effect of 313-hydioxy-2,3-dihydrowithanolide F against CCI4-induced hepatotoxicity has been assessed and the compound was found to possess marked protective effect. A comparison of the protective properties showed that it is more active than hydrocortisone on a weight basis.

Withania coagulans Extract Attenuates Histopathological Alteration and Apoptosis in Rat Brain Cortex Following Ischemia/Reperfusion Injury

“…The results of our study showed that WC extract administration before ischemia was able to reduce the pycnotic nucleus and widened the perinuclear space in the parietal brain cortex, which is in agreement with the findings of Budhiraja et al that showed cytoprotective effects of WC extract against CCL4-induced hepatotoxicity in rats (28). Another study showed that pretreatment with withania at a dose of 1000 mg/kg significantly improved the neurological deficit in rats (12).…”

Hypoglycemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dunal and Acacia arabica Lamk in Normal and Alloxan Induced Diabetic Rats

“…Hyperglycemia results in the generation of free radicals who can exhaust antioxidant defenses, leading to the disruption of cellular functions, oxidative damage to membranes and enhanced susceptibility to lipid peroxidation. [2,3] Flavonoids are one of the most numerous and widespread groups of phenolics in higher plants. [4][5][6][7][8] Some of them, due to their phenolic structure, are known to be involved in the healing process of free radical-mediated diseases, including diabetes.…”

Antidiabetic effect of Withania coagulans in experimental rats

“…The hot aqueous extract of W. coagulans fruits has been shown to exert hepatoprotective, antiinflammatory and antidiabetic effects (5,6). The same hot aqueous extract of W. coagulans fruits has also increased the glucose utilization in isolated rat hemidiaphragm cells (7).…”