Antidiabetic effect of Withania coagulans in experimental rats

Jaiswal, Dolly; Kumar, Prashant; Watal, Geeta

doi:10.1007/s12291-009-0015-0

Cited by 52 publications

(27 citation statements)

References 18 publications

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“…19 Huang et al evaluated the prospect of using sundried Cinnamom camphora leaf for the synthesis of nanosized noble metals of gold and silver under ambient conditions. 20 Aqueous extracts of Withania coagulans, 21 Cichorium endivia, 22 Sesbania sesban (L), 23 Scoparia dulcis, 24 and Trichosanthes dioica, 25 as well as the combination of Cassia auriculata and Aegle marmelos 26 were shown to have hypoglycemic and hypolipidemic effects in animals with experimentally induced diabetes. From the results of the different investigations mentioned above, it is evident that plants act as a natural reservoir for medicinal agents and avoid the common side effects of synthetic chemicals.…”

Section: Introductionmentioning

confidence: 99%

Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

Daisy¹,

Saipriya²

2012

IJN

199

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Cassia fistula stem bark was used for the preparation of aqueous extract and synthesis of gold nanoparticles to evaluate the hypoglycemic effects of the plant. The synthesized gold nanoparticles were characterized by ultraviolet-visible spectroscopy for their absorbance pattern, Fourier transform infrared spectroscopy to identify possible functional groups, and scanning electron microscopy to determine the size of the nanoparticles. The present investigation reports the efficacy of the gold nanoparticles as promising in the treatment of hyperglycemia. Body weight, serum glucose concentrations, liver function tests, kidney function tests, and lipid profile were analyzed. A significantly larger decrease in serum biochemistry parameters and an increase in body weight, total protein levels, and high-density lipoprotein were observed in rats with streptozotocin-induced diabetes treated with gold nanoparticles than in the ones treated with the aqueous extract. The results of this study confirm that C. fistula gold nanoparticles have promising antidiabetic properties.

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Section: Introductionmentioning

confidence: 99%

Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

Daisy¹,

Saipriya²

2012

IJN

199

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“…Therefore, improvement of antioxidant enzyme activities may help prevent neuronal damage. It has been accepted that Withania coagulans has strong antioxidant effects at the effective dose of 1000 mg/kg (18,19) for investigation of its effects on antioxidant status and striatal neurons after brain ischemia.…”

Section: Discussionmentioning

confidence: 99%

Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat

Mahmoudzadeh‐Sagheb

Heidari

Sarbishegi

2017

Jundishapur J Nat Pharm Prod

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Background: Withania coagulans is a traditional plant that possesses diverse pharmacological characteristics including antihyperglycemic, anti-hyperlipidemic, antitumor, anti-inflammatory, and antioxidant effects. Objectives: This study evaluated the effect of preischemic administration of Withania coagulans extract (WCE) on antioxidant status and histopathological alteration of the striatum region in rat model of brain global ischemia reperfusion (I/R). Methods: 48 male Wistar rats were divided into four groups (n = 12): Control, Sham operated (Sham), I/R, and WCE + I/R. The animals received WCE or distilled water by oral gavage for 30 days before I/R except the control group. I/R was induced by two common carotid obstructions for 30 minutes. Three days following I/R, the animals were sacrificed, the brain was removed, and striatum was dissected out. Antioxidant statuses such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, and malondialdehyde (MDA) level were measured and histological alteration was investigated in corpus striatum by Nissl and TUNEL staining. Results:The results showed that the CAT, SOD, and GPx activities decreased and MDA level increased in I/R group compare to the control group. Preischemic administration of WCE significantly decreased MDA level and increased antioxidant statuses in the striatum region compared to I/R group (P < 0.001). Histopathological analysis revealed that pretreatment with WCE markedly decreased necrotic and apoptotic neurons (P < 0.001) in striatum and reduced white matter injury induced by I/R. Conclusions: We concluded that WCE by its antioxidant and anti-inflammatory effects could modify ischemia reperfusion damage in rat striatum.

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“…Group 2 (Standard): treated with glipizide 2.5mg/kg body wt p.o. [7]. Group 3 (test): treated with bromocriptine 4.0 mg/kg body wt.…”

Section: Methodsmentioning

confidence: 99%

Bromocriptine, a Dopamine (D 2 ) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub–Therapeutic Doses to Ameliorate Hyperglycaemia

Kumar

Aithal²,

Baleed³

et al. 2013

JCDR

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Introduction: Bromocriptine, an ergot derivative, is an agonist at the dopamine 2 receptor and a sympatholytic. It is a well established drug in Parkinsonism, hyperprolactinaemia and acromegaly and it has various other clinical indications like induction of ovulation in female infertility. Bromocriptine has been evaluated in alloxan induced diabetic rats for its anti-hyperglycaemic effect with and without simultaneous use of glipizide.Methods: Diabetes was induced in albino rats by giving a single subcutaneous injection of alloxan in a dose of 150 mg/kg body weight. After 72 hours of giving alloxan injection, depending upon their blood glucose levels (350mg/dl and above), the rats were included into the study and they were divided into four groups, each comprising of 6 rats (n=24): Group 1 which was taken as control was given distilled water. Group 2 was treated with glipizide, a standard drug. Group 3 was treated with the test drug, bromocriptine and Group 4 was treated with sub therapeutic doses of test and standard drugs. The drugs were given to the diabetic rats once daily by oral route for 30 consecutive days, in order to assess their effects in terms of reduction in blood glucose levels. Blood glucose was estimated on 0 Results and Conclusion: Bromocriptine, which was used alone, lowered the blood glucose levels appreciably; whereas the concomitant administration of bromocriptine and glipizide in sub therapeutic doses produced a much more appreciable reduction.The results which were obtained in the group which received simultaneous administration of test and standard drugs in sub therapeutic doses were comparable to those of the group which received reference drug, glipizide. Hence, it can be concluded that bromocriptine may serve as a valuable adjunct to available anti-diabetic medication. INTRODUCTIONDiabetes is an "iceberg" disease. The increasing worldwide incidence of Diabetes Mellitus (DM) in adults is a global public health burden. Diabetes mellitus is a group of heterogenous disorders in which carbohydrate metabolism is reduced, while those of proteins and lipids are increased. Hyperglycaemia is a common end point for all types of DM and it is an important parameter which can be assessed to evaluate the effectiveness of anti-diabetic drugs. The goals of therapy for diabetes are to alleviate the symptoms which are related to hyperglycaemia and to prevent or reduce the acute and chronic complications of diabetes. Because of its multi-factorial pathogenesis, restoration of normoglycaemia is difficult to achieve and it requires multiple anti-diabetic medications in combination, to produce an additive effect. Therefore, the development of antidiabetic agents that have novel mechanisms of action and can be used in combination with currently approved medications for the treatment of type 2 Diabetes mellitus, is highly desirable.The idea of using bromocriptine for the treatment of type-2 diabetes came while the metabolism of migratory birds was studied, in which they develop seasonal insulin resist...

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Antidiabetic effect of Withania coagulans in experimental rats

Abstract: ABSTRACT

Cited by 52 publications

References 18 publications

Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat

Bromocriptine, a Dopamine (D 2 ) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub–Therapeutic Doses to Ameliorate Hyperglycaemia

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