Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat

Mahmoudzadeh‐Sagheb, Hamidreza; Heidari, Zahra; Sarbishegi, Maryam

doi:10.5812/jjnpp.65051

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…4 and Withanolide A Fig. 10, both of which have neuroprotective properties by enhancing the strength of dendritic and axon regeneration, as well as the ability to re-establish synapses in neurons 31 .…”

Section: Neuroprotectivementioning

confidence: 99%

Untitled

2023

IJPSR

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Withania species, from the East Mediterranean to South Asia, may be found worldwide. Withania coagulans and Withania somnifera are two species found in Pakistan 2 . Withania is a flowering plant of the Solanaceae family with roughly 23 species endemic to North Africa, the Middle East and the Canary Islands 3 . In various sections of Afghanistan, Pakistan, India, and Nepal, W. coagulans is prevalent. It may be found in Punjab, Rajasthan, Simla, Kumaun and Garhwal in India 4 .

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Section: Neuroprotectivementioning

confidence: 99%

Untitled

2023

IJPSR

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“…The use of medicinal plants and traditional medicine has a long history in many countries, including Iran. Nowadays, using medicinal plants in the treatment of various diseases is increasing due to better compatibility with human body physiology and having fewer side effects (5)(6)(7)(8)(9)(10)(11). Most plants and herbs contain substances to prevent cancer, which can exert their effects in different stages of the growth of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Anticancer Effects of Hydroalcoholic Extracts of Camellia sinensis and Lepidium sativum L on HeLa Cell Line

et al. 2020

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Background: The antioxidative activity of green tea and garden cress extract is of interest in cancer. Objectives: The current study aimed at evaluating the effect of hydroalcoholic extracts of Lepidium sativum (cress) and Camellia sinensis (green tea) on the culture medium of the HeLa cell line. Methods: Dulbecco’s Modified Eagle’s medium (DMEM) containing 10% fetal bovine serum (FBS) was used to culture HeLa cells, which was exposed to the different concentrations of green tea and cress extracts at 24 hours and 48 hours. Cell viability and apoptotic cells were quantified by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide or MTT assay and propidium iodide, respectively. Results: The highest percentage of growth inhibition (85%) was observed at 100 μg/mL of the green tea extract after 48-hour treatment. The percentage of growth inhibition at 24 h after treatment was 83% for green tea (P > 0.05). The high growth inhibition percentage of HeLa cells at 100 μg/mL of cress extract at 24 hours and 48 hours (49.8%) after treatment was 27.92% and 49.8%, respectively (P > 0.05). Additionally, the cell apoptosis assay indicated that green tea and cress extracts had toxic effects on the HeLa cells. This effect was highest at the concentration of 100 μg/mL and more evident in green tea. Conclusions: It can be concluded that green tea extract compared with cress had a more cytotoxic effect against cervical cancer.

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