Anti-inflammatory activity of 31-hydroxy-2,3-dihydro-withanolide F has been assessed and it was found to possess marked effects in sub-acute inflammation. A comparison of the anti-inflammatory properties showed that it is approximately 5 times more active than phenylbutazone and equally active to that of hydrocortisone on weight basis. The withanolide did not exhibit any effect on CNS.
Protective effect of 313-hydioxy-2,3-dihydrowithanolide F against CCI4-induced hepatotoxicity has been assessed and the compound was found to possess marked protective effect. A comparison of the protective properties showed that it is more active than hydrocortisone on a weight basis.
Anti-inflammatory activity and protective effect against CC!4-induced hepatotoxicity of alcoholic extract of leaves of Withania somnifera have been assessed. The leaves were found to possess marked effects in subacute inflammation and hepatotoxicity. A comparison of the anti-inflammatory properties revealed the extract at 1 g/kg dose to be as active as 50 mg/kg of phenylbutazone and 10 mg/kg of hydrocortisone. The protective effect of the extract at 1 glkg dose against CCI4induced hepatotoxicity was comparable to 10 mg/kg of hydrocortisone.
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