Context:Oral lichen planus (OLP) is a potentially malignant disease with a prevalence rate of 0.5–2.2%. It is a T-cell-mediated autoimmune disease, in which cytotoxic CD8+ T-cells trigger apoptosis of the basal cells of oral epithelium. The reported progression of OLP to oral squamous cell carcinoma (OSCC) ranges from 0.4% to 6.5%. Apoptosis plays a major role in the maintenance of tissue homeostasis. The evasion of apoptosis in the form of dysregulation of inhibitors of apoptosis proteins (IAPs) may lead to malignant transformation. Survivin belongs to the second gene family of IAPs, which is overexpressed in many tumors such as OSCC and gastric carcinomas, and its expression is widely involved in apoptosis as well as in tumor metastasis.Materials and Methods:Sections were obtained from the paraffin-embedded archival blocks of patients diagnosed histologically as OLP, and cases with normal epithelium were used for comparison whereas cases with OSCC were used as positive control.Results:We analyzed the expression of survivin in OLP and normal epithelium. Survivin expression with moderate intensity was seen in the cells of basal layer with nuclear positivity in cases of OLP, whereas mild to nil expression was seen in normal epithelium with nuclear and cytoplasmic positivity in different layers.Conclusions:Survivin positivity was seen predominantly in the basal cells of OLP suggesting increased longevity of these cells which in turn might acquire dysplastic changes leading to increased risk of malignant transformation of this premalignant condition. Although the conversion rate may be low, the potential exists in the indolent course of the disease.
Oculodentodigital dysplasia (ODDD) is a multisystem congenital disorder characterized by abnormal facial development, deformed limbs and dentition. This report describes a rare incidence of ODDD-linked dermatological, cardiac, dental, and neurologic manifestations noted in an Indian child patient.
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is relatively uncommon lesion presenting clinically as ulceration of the oral
mucosa with a chronic course associated with delayed healing. Chronic irritation causing trauma to the oral mucosa is considered as major
causative factor. The most commonly affected site of the lesion appears to be Tongue and Buccal mucosa. This lesion represents clinically as ulcer
with indurated margins mimicking malignancy, causing diagnostic challenge for the dentists. Histologically characterized by breach in the
epithelium exposing underlying connective tissue inltrated with dense amount of inammatory cells predominantly of eosinophils penetrating
the underlying mucle. It is important to diagnose the lesion histologically to rule out malignancy and to treat appropriately. However the lesion
resolves on its own or with minimal and conservative treatment. In this review we present four case series of clinically manifesting
ulceroproliferative lesions on buccal mucosa and diagnosed as TUGSE,based on clinical and histopathological features.
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