It has been demonstrated that the exposure of biological systems to magnetic fields (MFs) can produce several beneficial effects: tissue recovery in chronic wounds, re-establishment of blood circulation after tissue ischemia or in necrotic tissues, improvement after epileptic episodes, angiogenesis, etc. In the current study, the effects of extremely low frequency (ELF) MF on the capillaries of some circumventricular organs (CVOs) are demonstrated; a vasodilator effect is reported as well as an increase in their permeability to non-liposoluble substances. For this study, 96 Wistar male rats (250 g body mass) were used and divided into three groups of 32 rats each: a control group (no treatment); a sham ELF-MF group; and an experimental group subjected to ELF-MF (120 Hz harmonic waves and 0.66 mT, root mean square) by the use of Helmholtz coils. All animals were administered colloidal carbon (CC) intravenously to study, through optical and transmission electron microscopy, the capillary permeability in CVOs and the blood-brain barrier (BBB) in brain areas. An increase in capillary permeability to CC was detected in the ELF-MF-exposed group as well as a significant increase in vascular area (capillary vasodilation); none of these effects were observed in individuals of the control and sham ELF-MF groups. It is important to investigate the mechanisms involved in the phenomena reported here in order to explain the effects of ELF-MF on brain vasculature.
Thep resent work deals with the effects of extremely low frequency electromagnetic Thep resent work deals with the effects of extremely low frequency electromagnetic Thep resent work deals with the effects of extremely low frequency electromagnetic Thep resent work deals with the effects of extremely low frequency electromagnetic fields (ELF-EMF)o nb lood vessels permeability to non liposoluble substances of the fields (ELF-EMF) on blood vessels permeability to non liposoluble substances of the fields (ELF-EMF) on blood vessels permeability to non liposoluble substances of the fields (ELF-EMF) on blood vessels permeability to non liposoluble substances of the circumventricular organs (CVO) of adult rats. Male Wistar adult rats were exposed to ELF-EMF circumventricular organs (CVO) of adult rats. Male Wistar adult rats were exposed to ELF-EMF circumventricular organs (CVO) of adult rats. Male Wistar adult rats were exposed to ELF-EMF circumventricular organs (CVO) of adult rats. Male Wistar adult rats were exposed to ELF-EMF and vascular permeability to colloidal carbon was investigated with theu se of histological and vascular permeability to colloidal carbon was investigated with theu se of histological and vascular permeability to colloidal carbon was investigated with theu se of histological and vascular permeability to colloidal carbon was investigated with theu se of histological techniques. Results were compared to corresponding data from sham-exposeda nd control techniques.R esults were compared to corresponding data from sham-exposeda nd control techniques.R esults were compared to corresponding data from sham-exposeda nd control techniques.R esults were compared to corresponding data from sham-exposeda nd control groups of animals. Exposure to ELF-EMF increased theCVO vascular permeability to colloidal groups of animals. Exposure to ELF-EMF increased theCVO vascular permeability to colloidal groups of animals. Exposure to ELF-EMF increased theCVO vascular permeability to colloidal groups of animals. Exposure to ELF-EMF increased theCVO vascular permeability to colloidal carbon intravascularly injected, particularly in the subfornical organ, them edian eminence, the carbon intravascularly injected, particularly in the subfornical organ, them edian eminence, the carbon intravascularly injected, particularly in the subfornical organ, them edian eminence, the carbon intravascularly injected, particularly in the subfornical organ, them edian eminence, the pineal gland andthe area postrema. pineal gland andthe area postrema. pineal gland andthe area postrema. pineal gland andthe area postrema.
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