“…They have also been used as coadjuvants in depression [Carpenter, 2006] and pain treatment [Eccles, 2005; Thomas et al, 2007] and have been associated with progenitor cell differentiation in the endothelium, and angiogenesis as well [Tepper et al, 2004]. MF have been associated with stem cell differentiation in the central nervous system (CNS) [Feria‐Velasco et al, 1998; Arias‐Carrion et al, 2004]; they increase the blood–brain barrier (BBB) permeability in some brain areas [Salford et al, 1994; Gutiérrez‐Mercado et al, 2008]; and appear to be of some benefit in the treatment of some types of epileptic episodes [Ossenkopp and Cain, 1988; Seyhan and Canseven, 2006; Ransohoff, 2009]. However, the subject has been highly controversial since other authors have challenged the theory of MF effects upon the nervous system's biology [Preston et al, 1979; Fritze et al, 1997].…”