Efficacy and Safety Evaluation of Systemic Extremely Low Frequency Magnetic Fields Used in the Healing of Diabetic Foot Ulcers–Phase II Data

Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials

“…In a randomized, double‐blind and placebo‐controlled clinical trial, patients who receive PEMF therapy with frequency of 12 Hz and intensity of 12 G for 60 min during one session show 18% decrease in wound size, 14% increase in capillary diameters, 28% increase in cutaneous capillary blood velocity and 16% increase in skin blood flow, whereas 10% decrease in wound size in the sham MF group after 14 sessions within 3 weeks 135 . With forearm and thorax exposure to ELF‐MF, a clinical phase 2 study through a long‐term follow‐up shows that there are no adverse effects or ulcer recurrences at the original ulcer sites in DFU patients 136 . However, there is no sham ELF‐EMF treated group, it is hard to evaluate the effectiveness of ELF‐EMF on DFUs through this trial.…”

“…135 With forearm and thorax exposure to ELF-MF, a clinical phase 2 study through a long-term follow-up shows that there are no adverse effects or ulcer recurrences at the original ulcer sites in DFU patients. 136 However, there is no sham ELF-EMF treated group, it is hard to evaluate the effectiveness of ELF-EMF on DFUs through this trial. Technologic advances allow the development of EMF device which are portable for daily use.…”

Potensi Medan Magnet Extremely Low Frequency (Elf) Untuk Terapi Diabetes

“…Selain itu, beberapa penelitian juga menunjukkan bahwa medan magnet ELF membantu penyembuhan luka dan mengurangi risiko komplikasi pada penderita diabetes. Perawatan dengan menggunakan ELF pada ulkus kaki terbukti dapat mengaktikan sel monokulear darah perifer (PBMC), yang mampu mempercepat penyembuhan luka setelah diangkut menuju lokasi ulkus oleh darah (Cañedo-Dorantes et al, 2015). Paparan medan magnet ELF memodulasi rofil sitokin yang mendorong transisi dari kondisi proinflamasi kronis menjadi antiinflamasi dalam proses penyembuhan luka.…”

PCA Destekli J48 Algoritmasıİle Manyetik Alanla Tedavi Edilen Diyabetik Sıçanların Biyokimyasal ve Biyomekanik Verilerinin Sınıflandırılması

“…Basset Previous studies have reported that magnetic field applications, which are used as a non-invasive method in the treatment of many diseases, may produce positive effects on different tissues [10][11][12][13] . It has been reported that lowfrequency magnetic field applications help peripheral blood mononuclear cells to warn of diseases such as angiogenesis and diabetic foot ulcer [14] . Pulsed Magnetic Field (PMF) applications are considered to be a very important alternative treatment method for inflammatory pain resulting from pharmacological agents with toxicity and side effects [15][16][17] .…”