Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials

Lv, Huanhuan; Liu, Junyu; Zhen, Chenxiao; Wang, Yijia; Wei, Yunpeng; Ren, Weihao; Shang, Peng

doi:10.1111/cpr.12982

Cited by 43 publications

(33 citation statements)

References 145 publications

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“…In a mixed etiology leg ulcer, a combined 9-week treatment including hyperbaric oxygen, an extremely low-frequency variable magnetic field, and low-energy light radiation resulted in complete healing and subsequent pain relief [40]. Magnetic fields seem to have promising application prospects also in diabetic wound healing, notwithstanding the lack of general agreement on the mechanisms underlying its biological and therapeutic effects [41].…”

Section: Discussionmentioning

confidence: 99%

High-Intensity, Low-Frequency Pulsed Electromagnetic Field as an Odd Treatment in a Patient with Mixed Foot Ulcer: A Case Report

Roberti¹,

Marcianò²,

Casarella³

et al. 2022

Reports

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Lower-extremity ulcers are associated with an increasing prevalence and significant economic and social costs. To date, there is no high-quality evidence related to an optimal treatment algorithm. A multimodal approach is needed particularly in patients with comorbidity and polytherapy. Herein, we report the case of a 94-year-old Caucasian female with comorbidity and polytherapy who was admitted to our observation for a history (1 year) of chronic painful malleolar mixed ulcer. After clinical evaluation, she was treated with a twice daily pain relief therapy and with a weekly diamagnetic therapy protocol plus a local treatment. During the clinical examination, we documented a statistically significant improvement in both pain (VAS score from 8 to 2 p < 0.01) and foot ulcer (surface reduction from 6 cm × 4 cm to 2 cm × 2 cm, p < 0.01) at the sixth week of combined treatment. The ulcer completely healed at the ninth week. This is the first study to document the effect of diamagnetic therapy as an add-on therapy in the management of wound healing. In conclusion, even if high-quality evidence is still lacking, diamagnetic therapy might represent an interesting option as an add-on treatment for ulcer.

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Section: Discussionmentioning

confidence: 99%

High-Intensity, Low-Frequency Pulsed Electromagnetic Field as an Odd Treatment in a Patient with Mixed Foot Ulcer: A Case Report

Roberti¹,

Marcianò²,

Casarella³

et al. 2022

Reports

View full text Add to dashboard Cite

show abstract

“…Several therapies are available in clinical practice and include topical agents, dressings, engineered tissue, cell therapy, growth factors, devices and herbal/natural remedies [1]. Furthermore, novel therapies such as magnetic fields have been employed and show great potential in promoting wound healing and have already been utilized in the management of diabetic wounds [39]. The potential of polymeric wound dressing has also been evaluated in wound care management [40].…”

Section: Discussionmentioning

confidence: 99%

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

et al. 2021

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Ineffective healing and treatment of foot ulcers can lead to an infection and gangrene of the wound area that ultimately results in the loss of the limb. The incidence of foot ulcers is higher in patients with diabetes, peripheral vascular disease and kidney disease. Accordingly, this study was undertaken to assess the ability of foot bathing in CO2-enriched water to heal foot ulcers. The design was a double-blinded, randomized, placebo-controlled study. Patients with at least one foot ulcer were randomized to receive either a treatment with bath therapy at 37 ± 0.5 °C containing either 1000–1200 ppm CO2-enriched tap water (the intervention) or non-carbonated tap water at 37 ± 0.5 °C (the control group). Treatment was conducted three times/week for 15 min per session for up to 16 weeks for a total of 48 treatment sessions. Before and at the end of every treatment month, wound size, wound area oxygenation and the ankle brachial index were measured. In addition, the McGill pain questionnaire was conducted. Blood was also collected at these time points (for a total of five collections) for the measurement of different biomarkers. While no significant differences (p < 0.05) in the group/time interaction effect were observed, a clear separation within the wound area reduction/wound area/oxygenated Hb outcomes was seen between placebo (control) and treatment (CO2) group. This pilot study is suggestive that bathing in CO2-enriched water may accelerate the healing of foot ulcers.

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“…Haemostasis represents the initiation of wound healing (0‐several hours after injury), during which the clotting factors are immediately released, platelets are activated and aggravated, thus resulting in the formation of blood clot 19 . The abnormalities of platelets in diabetic mellitus (DM) are characterised to be hyperactive with increased autophagy, activation, adhesion and aggregation, causing wound healing dysfunction 20 …”

Section: Lncrnas Involved In Haemostasismentioning

confidence: 99%

Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance

Kuai

Jiang²,

et al. 2021

International Wound Journal

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Diabetic wounds are a protracted complication of diabetes mainly characterised by chronic inflammation, obstruction of epithelialization, damaged blood vessels and collagen production (maturation), as well as neuropathy. As a non‐coding RNA (ncRNA) that lack coding potential, long non‐coding RNAs (lncRNAs) have recently been reported to play a salient role in diabetic wound healing. Here, this review summarises the roles of lncRNAs in the pathology and treatments of diabetic wounds, providing references for its potential clinical diagnostic criteria or therapeutic targets in the future.

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Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 43 publications

References 145 publications

High-Intensity, Low-Frequency Pulsed Electromagnetic Field as an Odd Treatment in a Patient with Mixed Foot Ulcer: A Case Report

High-Intensity, Low-Frequency Pulsed Electromagnetic Field as an Odd Treatment in a Patient with Mixed Foot Ulcer: A Case Report

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance

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