Background: The Aim of this study was to assess the role of platelet aggregation, mean platelet volume (MPV) and plasma fibrinogen levels in the pathogenesis of acute myocardial infarction (AMI).Methods: A prospective case control study was conducted on 30 cases of AMI and 30 normal healthy age and sex matched controls. The cases and controls were investigated for platelet aggregation studies (done in platelet rich plasma (PRP) using light transmission chrono-log optical aggregometer), MPV (measured by automated cell counter) and plasma fibrinogen levels (estimated by Clauss method).Results: The mean platelet aggregation (%) in cases AMI was 57.61±11.91 which was significantly higher compared with 35.00±10.40 for healthy controls (p<0.001). Using Receiver Operating Characteristic (ROC) analysis, most patients of AMI had a platelet aggregability of ≥49% on optical aggregometry (sensitivity = 83.3 % and specificity = 93.7%). The MPV (fL) in cases of AMI was 8.04±0.39 which was significantly larger when compared with 7.67±0.43 for controls (p= 0.001). The mean plasma fibrinogen concentration in cases of AMI was 383.1±48.3mg/dl which was significantly higher when compared with 271.33±57.7mg/dl for healthy controls (p<0.001).Conclusions: Platelet hyperaggregability, elevated MPV and plasma fibrinogen levels are found in patients with AMI and contribute significantly to risk of developing coronary thrombosis. These variables should be considered as additional screening tools to identify individuals at increased risk of developing AMI.
Background: The epidemiological spectrum of endocrine disorders in hospitalized patients is not much explored in developing countries. Therefore, the spectrum to visualize a complete picture of the endocrine-related disease is still missing.
Aims: The study aims to find the spectrum of endocrine-related-disorders in a hospitalized patient, characterize demographic variables, and the duration of hospital stay of patients.
Methods: This was a retrospective study of medical records of admitted cases between January 2014 to December 2018 in the Medicine Ward of BPKIHS. Records were retrieved from the Medical office and were entered into Excel and then transferred to SPSS and were analysed.
Result: Out of 26,590 admitted cases,1141 (4.3%) had endocrine-related-disease. This includes 565 males and 576 females (1.02: 1 ratio) with an overall mean age of 52.81 ± 16.21 years and median (IQR) age 53 (42-64) years. Among which 904 (79.2%) had Diabetes mellitus, 118 (10.3%) had Metabolic Disorders, 38 (3.3%) had Disorders of Thyroid gland, 38 (3.3%) had Other Nutritional Deficiencies, 29 (2.5%) had Disorders of other endocrine glands, 7 (0.6%) had other disorders of glucose regulation and pancreatic internal secretion, 5 (0.4%) had Overweight, obesity and other hyperalimentation, 2 (0.2%) had Malnutrition.
Conclusion: Diabetes and Metabolic disorders are the main components of the spectrum of endocrine disorders in admitted cases. Emphasizing the resources essential for further investigation will help both in dealing with and managing the cases of endocrine disorders.
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