Objective:
The study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.
Methods:
The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles, quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies both RCTs and Non-RCTs.
Results:
The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group [-5.94[-14.28, 2.41]. Two clinical trials showed a significant effect with pooled data [5.52[2.14, 8.91]. Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component [4.89 [0.16, 9.62] of quality of life [2.36 [-3.67, 8.39] when compared to comparison group.
Conclusion:
This meta-analysis suggested that lifestyle modification has potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies are needed to come to a firmer conclusion.
Background:
Increasing age and the added disadvantage of diabetic peripheral neuropathy (DPN) put the individual at a higher risk of falls and reduced functional fitness. However, there is a dearth of literature on multifactorial balance intervention, especially targeting the needs of older adults with DPN.
Objective:
The current study aimed to determine the effect of a multifactorial balance rehabilitation program on fall risk and functional fitness in older adults with DPN.
Method:
In this pre-post experimental study, 30 independently ambulating older adults (71.2 ± 4.70 years) with DPN, who were at risk of falling (timed up and go score ≥ 9.4 seconds), were recruited. Along with the standard care, all the participants received 12 weeks of the multifactorial balance rehabilitation program.
Results:
Fall risk using the Fullerton Advanced Balance scale and functional fitness using the Senior Fitness Test were measured at baseline and after 12 weeks of the intervention. The intervention reduced the risk of falling score significantly (MD= 6.17, p< .001). All six parameters of functional fitness improved after 12 weeks of intervention. The improvement in lower limb strength (MD=1.53 times), upper limb strength (MD=2.48 times), endurance (MD= 16.07 seconds), lower limb flexibility (MD= 2.02 inches), upper limb flexibility (MD= 1.47 inches), and dynamic balance (MD= 1.53 seconds) was statistically significant at p< 0.05.
Conclusion:
This study provided encouraging evidence about the potential of multifactorial balance rehabilitation to reduce the risk of falling and improve functional fitness in older adults with DPN.
other:
NA
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