Dissolution rates and apparent solubilities for synthetic hydroxyapatite in acetate buffers containing phosphate and strontium ions in the range of 10-3 to 10-2 M were determined under various pH and buffer conditions. Critical examination of the role of strontium with a physical model suggests that a calcium-strontium apatite surface complex may govern the driving force of the dissolution reaction.

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In contrast to earlier studies on aliphatic amines,23'27 this indicates that ion energetics can be a useful tool in characterizing the structural isomers of CaHeN"1'.In the cases of C2H5O4• isomer II and isomer III in both sets, it is seen that gaseous ion properties obtained from ion-molecule reaction chemistry studies are most useful in the interpretation of ion energetics data.

In vitro studies on the dissolution rate of cholesterol monohydrate crystals in micellar bile acid solutions showed that the addition of lecithin decreases the dissolution rate even though lecithin increases the equilibrium solubility of cholesterol in these solutions. The reduction in rates caused by lecithin was attributed to a large crystal-solution interfacial barrier. An effective permeability coefficient for the interfacial barrier was calculated to be around 1.5 x 10(-5) centimeter per second for the transport of cholesterol molecules.

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