Purpose -The purpose of this paper is to analyze the current state of the art and trends with regard to business process measurement by means of a systematic review of literature. Design/methodology/approach -The results are obtained through a systematic review carried out according to existing relevant guidelines. Additionally, a specific methodology through which to systematically obtain all the most important journals is followed. In total, 19 relevant articles are selected and later analyzed. A subsequent critical analysis of the data obtained is applied to identify the gaps in the current literature. Findings -A considerable effort has been made by researchers in the field of business process measurement, particularly in recent years. Many of the defined measures for business processes have been applied to models (approximately 77 per cent). Most of the initiatives concerning business measurement have been adapted from the software engineering field. A small percentage of the existing business process measures has been empirically validated. Originality/value -The results presented contribute towards providing an updated overview of the current state of research into business process measurement, in order to identify existing research gaps and concerns on which ongoing and future research efforts on this topic can be focused.
Alendronate are used as the first line of pharmacological treatment for osteoporosis; however, some of them do not respond adequately to therapy with alendronate. The aim of this study was to investigate the influence of combinations of potential risk alleles (genetic profiles) associated with the response to antiosteoporotic treatment in a cohort consisting of 82 postmenopausal women with primary osteoporosis receiving alendronate (70 mg administered orally per week) for one year. Bone mineral density (BMD; g/cm2) of the femoral neck and lumbar spine was measured. According to BMD change patients were divided in two groups: responders and non-responders to alendronate therapy. Polymorphic variants in CYP19, ER, IL-6, PTHR1, TGFβ, OPG and RANKL genes were determined and profiles generating from the combination of risk alleles. Results: 56 subjects were responders to alendronate and 26 subjects were non-responders. The carriers of A-C-T-C profile (constructed from rs700518, rs1800795, rs2073618, and rs3102735) were predisposed to response to alendronate treatment (P= 0.001). Our findings highlight the importance of identified profiles for pharmacogenetics of alendronate therapy in osteoporosis.
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