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Regional blood flow measurements were made using the radioactive microsphere technique of Rudolph and Heymann [13] before Histamine and 3 times after the i.v. infusion of 2 mg/kg morphine in 9 unanesthetized monkeys restrained in horizontally tilted primate chairs. The dose was chosen after response curves established its minimal but consistent hypotensive effects. Although little systemic hemodynamic change was observed, the morphine evoked significant increases in blood flow to the heart, brain and bone, which lasted up to 1¹/₂ h. The changes in regional blood flow outlasted the effects on blood pressure. Initially blood flow to the bronchial arteries was reduced to 50% of baseline. These changes were associated with depressed respiration, decreased pH and PO₂ and an increased PCO₂ of arterial blood. Arterial blood levels of histamine were not significantly changed after the morphine infusion; therefore, histamine cannot be considered the mediator of the changes in regional blood flow.

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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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