Replenishing neurons may represent the best therapy for, otherwise progressive and fatal, neurological diseases. Clinical trials show that cell integration in a patient’s brain tissue is limited by poor cell...
Active pharmaceutical ingredient
(API) purity is of major concern
for pharmaceutical companies and the medical community. Reaching ultralow
limits of genotoxic impurities (GTIs), imposed by strict legislation,
is often time consuming and economically challenging. Therefore, there
is a call for efficient unit operations able to remove GTI with minimal
API losses from the organic solvent postreactional streams. This study
reports for the first time a new approach to improve the performance
of polybenzimidazole (PBI), a solvent-stable polymer, to efficient
GTI removal. Two families of GTIs are considered, and the discovery
that the use of specific thermal and pH conditioning of PBI adsorbers
improves GTI removal efficiency is reported. Electrospun fibers are
explored, aiming at process versatility. Similar removals of GTI,
more than 97%, are achieved with virtually no API loss.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.