Polyetheretherketone (PEEK) is a semi-crystalline linear polycyclic thermoplastic that has been proposed as a substitute for metals in biomaterials. PEEK can also be applied to dental implant materials as a superstructure, implant abutment, or implant body. This article summarizes the current research on PEEK applications in dental implants, especially for the improvement of PEEK surface and body modifications. Although various benchmark reports on the reinforcement and surface modifications of PEEK are available, few clinical trials using PEEK for dental implant bodies have been published. Controlled clinical trials, especially for the use of PEEK in implant abutment and implant bodies, are necessary.
Aloe vera has been investigated potential use in tissue engineering. Its bioactive compounds interact with growth factor receptor on the fibroblast and stimulate cells proliferation. The aim of this study was to investigate the proliferation of fibroblast cells on wound healing process of Cavia cobaya dental extraction using scaffold combination chitosan and Aloe vera. Cavia cobaya male with 300-350 grams of weight and in the age of 3 to 3.5 months. It divided into ten groups (n=5). For Treatment groups, Aloe vera scaffold(Av); Chitosan Scaffold (Ch); Scaffold combination chitosan-Aloe vera (Ch-Av) and scaffold combination chitosan- Aloe vera- hidroksiapatit(Ch-Av-HA) were applied into the socket of dental extraction. For control group, which were not given scaffold. Cavia cobaya were decaputated at 7 and 14 days and the jaw in the treated regions and control group were cut for Histopatology Anatomy examination to investigate the proliferation of fibroblast cells. Data were analyzed using One way Anova test. The proliferation of fibroblast cells were found higher in the group which given Av-Ch and Av-Ch-HA scaffold. The result showed significant differences in proliferation of fibroblast cells for 7 and 14 days observation compared to control group (p<0,05). The application of scaffold combination Chitosan and Aloe vera accelerate the wound healing process of Cavia cobaya dental extraction.
Kerusakan tulang alveolar dalam kasus kedokteran gigi dapat disebabkan oleh penyakit periodontal, trauma pasca pencabutan gigi, post enukleasi kista, dan post operasi tumor. Kitosan merupakan bahan yang sering digunakan sebagai bahan graft namun penggunaannya sendiri kurang osteokonduktif apabila tidak dikombinasikan dengan bahan lain. Kitosan dapat dikombinasikan dengan kolagen dalam bentuk sediaan scaffold 3D untuk penyembuhan kasus kerusakan tulang. Untuk mengetahui sifat osteokonduktifitas bahan kitosan dan kolagen berupa sediaan scaffold 3D. Scaffold 3D kitosan dan kolagen dapat menirukan struktur dan fungsi alami dari protein ekstraseluler matriks, membentuk struktur unik yang dapat meningkatkan kekuatan mekanik, menurunkan tingkat biodegradasi, dan kombinasi keduanya dapat menghasilkan ion kompleks yang berperan untuk merangsang proliferasi dan diferensiasi sel sehingga dapat mempercepat proses penyembuhan tulang. Scaffold 3D kitosan dan kolagen berperan dalam proses penyembuhan tulang karena kedua bahan tersebut membentuk senyawa ion kompleks yang dapat meningkatkan sifat osteokonduktifitas.
Introduction. Alveolar bone defect in dentistry can be caused by injury after tooth extraction, periodontal disease, enucleation of a cyst, and tumor surgery. Scaffold in tissue engineering is an important material that can stimulate osteogenesis process. Lymphocyte cells have a role in promoting and accelerating the proliferation of supporting cells like osteoblast to accelerate the bone regeneration process.Objective. The purpose of this study was to determine the effect of chitosan-collagen chicken shank collagen used as scaffold for bone regeneration through lymphocyte cell proliferation.Method. Twelve Wistar rats (Rattus norvegicus) were prepared as animal models in this study. Bone defects are intentionally made in both the right and left femur bones of the rat. Total samples were 24 divided into four groups: Group 1 as a control Group using 3% CMC-Na, Group 2 using chitosan scaffold only, Group 3 using chitosanchicken shank collagen scaffold (50:50), and Group 4 using chitosan-chicken shank collagen scaffold (80:20). The animals were sacrificed on the 5 th day, and histopathological examination was carried out to observe the number of lymphocyte cells.Results. Significant differences between all groups can be showed in the one-way ANOVA test (p value>0.05). The highest lymphocyte cells were found in Group 3 with chitosan-chicken shank collagen scaffold (50:50). Conclusion.The chitosan-chicken shank collagen used as scaffold can increase the bone regeneration process through increased lymphocyte cell proliferation.
Background: Acanthus ilicifolius L. has antifungal potential and makes it possible to be a candidate for denture cleanser. This study aims to evaluate the effect of effervescent Acanthus ilicifolius L. extract on antifungal properties and flexural strength acrylic after immersion for three duration times.Method: Extracts were made by maceration method with ethanol. For the antifungal test, effervescent Acanthus ilicifolius L extract was prepared by combining the Acanthus ilicifolius L extract 4% and sodium perborate with two ratios, 1:7 and 1:14. The microdilution method was carried out. Effervescent Acanthus ilicifolius L extract 4% with ratio 1:7 was prepared for the flexural strength test. The fifty-four heat-cured acrylic resin (20x10x2.5mm) were fabricated and divided into 3 groups. Group 1 was immersed in aquadest (control); Group 2 was immersed in sodium perborate; Group 3 was immersed in effervescent Acanthous ilicifolius L. extract. Each group was immersed for 15 min, 8, and 56 hours (n=6). The flexural strength test was performed using Universal Testing Machine.Result: Effervescent Acanthus ilicifolius L. extract exhibited antifungal activity which increased in an effervescent Acanthus ilicifolius L extract-dependent manner significantly (0.57 to 0.50 OD). There were no significant differences between sodium perborate, effervescent_AI1 (1:7) and effervescent_AI2 (1:14). The flexural strength was found to be within the range of 66.1 - 68.3 MPa. There were no significant differences between groups (p < 0.05).Conclusion: Effervescent Acanthus ilicifolius L extract with the ratios 1:7 had a good antifungal effect and appropriate flexural strength after immersion for 15 min, 8, and 56 hours.
Objective This study aimed to analyze interaction between glycosaminoglycan-acemannan as a scaffold material and toll-like receptor-2 (TLR-2) receptor, which predicted the osteogenesis potency on alveolar bone healing (in silico analysis). Materials and Methods Docking interaction between glycosaminoglycan-acemannan and TLR-2 receptor using the Molegro Virtual Docker (MVD) program. The compounds of glycosaminoglycan-acemannan and TLR-2 receptor with the structure in the form of two- and three-dimensional images were analyzed, as well as the most stable structure. It was observed the interaction of the ligand on the cavity of the TLR-2 receptor structure. The energy required for the ligand and receptor interaction (Moldock score) was calculated with MPD program. Results The chemical structure shows that glycosaminoglycan-acemannan is capable binding to the TLR-2 receptor with hydrogen bonds and strong steric interaction. The docking results were detected for five cavities where the compound binds to the TLR-2 receptor. The Moldock score of the ligand on the CAS-LYS-LEU-ARG-LYS-ILE-MSE[A] ligand was −95,58 Kcal/mol, that of acemannan was −91,96 Kcal/mol, and for glycosaminoglycan −61,14 Kcal/mol. Conclusion The compound of glycosaminoglycan-acemannan as a scaffold material is able to bind with a TLR-2 target receptor, which predicted osteogenesis activity on alveolar bone healing supported by in silico analysis.
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